New development of studies on the interaction between cell membranes and drugs using sensors
New development of studies on the interaction between cell membranes and drugs using sensors
批准号:
22590036
负责人:
KATSU Takashi
金额:
$3.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
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英文摘要
We analyzed how cationic porphyrins and xanthene dyes photoinactivated cell membranes using electrochemical sensors, such as ion sensor and oxygen electrode. Furthermore, we applied a K+sensor to cell membrane permeability assay and advanced(1) the development of antimicrobial peptides with low hemolytic activity;(2) the comparative study of the membrane-permeabilizing activities of mastoparans and related histamine-releasing agents in bacteria, erythrocytes, and mast cells; and(3) the investigation of new substances that enhance the outer membrane of Gram-negative bacteria.
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光活性化されたポルフィリンの細胞膜に対する作用
光活化卟啉对细胞膜的影响
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[加藤久登, 中西由佳, 駒越圭子, 井上 剛, 齋藤啓太, 増田和文, 片岡洋行, 勝 孝]
通讯作者:
勝 孝
DOI:
10.2116/analsci.26.903
发表时间:
2010-08
期刊:
Analytical Sciences
影响因子:
1.6
作者:
[K. Komagoe;Hiroaki Takeuchi;Tsuyoshi Inoue;T. Katsu]
通讯作者:
K. Komagoe;Hiroaki Takeuchi;Tsuyoshi Inoue;T. Katsu
DOI:
10.1016/j.bbamem.2010.10.007
发表时间:
2011-01-01
期刊:
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
影响因子:
3.4
作者:
[Nakao, Satoshi, Komagoe, Keiko, Katsu, Takashi]
通讯作者:
Katsu, Takashi
キサンテン系色素による細菌および赤血球膜機能の光不活性化
呫吨染料光灭活细菌和红细胞膜功能
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[加藤久登, 駒越圭子, 中西由佳, 松山佳澄, 井上 剛, 勝 孝]
通讯作者:
勝 孝
キサンテン系色素による細胞膜の光不活性化
使用呫吨染料光灭活细胞膜
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[松山佳澄, 中西由佳, 加藤久登, 駒越圭子, 井上 剛, 勝 孝]
通讯作者:
勝 孝
共 19 条
In situ monitoring of drug action using electrochemical sensors
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批准号:25460036
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.33万
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财政年份:2013
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负责人:KATSU Takashi
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依托单位:
Development and application of sensors selective to biologically active substances
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批准号:19590039
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.91万
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财政年份:2007
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负责人:KATSU Takashi
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依托单位:
Development and application of high-performance ion-selective electrodes
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批准号:16590027
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.24万
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财政年份:2004
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负责人:KATSU Takashi
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依托单位:
Development of drug electrodes with high sensitivity and selectivity
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批准号:10672019
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.24万
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财政年份:1998
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负责人:KATSU Takashi
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依托单位:
Development of electrochemical sensors responding to biologically active substances
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批准号:08672477
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.41万
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财政年份:1996
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负责人:KATSU Takashi
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依托单位:
Development and application of ion-selective electrodes
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批准号:06672144
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.34万
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财政年份:1994
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负责人:KATSU Takashi
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依托单位:
Amphiphile-induced incorporation of a substance into cells
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批准号:03671026
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.28万
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财政年份:1991
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负责人:KATSU Takashi
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依托单位:
Mechanism of Biological Membrane Damage Induced by Amphiphilic Drugs and Peptides
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批准号:01571178
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.34万
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财政年份:1989
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负责人:KATSU Takashi
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依托单位:
Action mechanism of cationic drugs increasing the permeability of an outer membrane of Gram-negative bacteria
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批准号:62570967
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.28万
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财政年份:1987
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负责人:KATSU Takashi
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依托单位:
海外基金