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New development of studies on the interaction between cell membranes and drugs using sensors

New development of studies on the interaction between cell membranes and drugs using sensors
利用传感器研究细胞膜与药物相互作用的新进展
批准号:
22590036
负责人:
KATSU Takashi
金额:
$3.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012

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中文摘要
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英文摘要
We analyzed how cationic porphyrins and xanthene dyes photoinactivated cell membranes using electrochemical sensors, such as ion sensor and oxygen electrode. Furthermore, we applied a K+sensor to cell membrane permeability assay and advanced(1) the development of antimicrobial peptides with low hemolytic activity;(2) the comparative study of the membrane-permeabilizing activities of mastoparans and related histamine-releasing agents in bacteria, erythrocytes, and mast cells; and(3) the investigation of new substances that enhance the outer membrane of Gram-negative bacteria.
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DOI: --
发表时间: 2013
期刊:
影响因子: --
作者: [加藤久登, 中西由佳, 駒越圭子, 井上 剛, 齋藤啓太, 増田和文, 片岡洋行, 勝 孝]
通讯作者: 勝 孝
DOI: 10.2116/analsci.26.903
发表时间: 2010-08
期刊: Analytical Sciences
影响因子: 1.6
作者: [K. Komagoe;Hiroaki Takeuchi;Tsuyoshi Inoue;T. Katsu]
通讯作者: K. Komagoe;Hiroaki Takeuchi;Tsuyoshi Inoue;T. Katsu
DOI: 10.1016/j.bbamem.2010.10.007
发表时间: 2011-01-01
期刊: BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
影响因子: 3.4
作者: [Nakao, Satoshi, Komagoe, Keiko, Katsu, Takashi]
通讯作者: Katsu, Takashi
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [加藤久登, 駒越圭子, 中西由佳, 松山佳澄, 井上 剛, 勝 孝]
通讯作者: 勝 孝
19
    In situ monitoring of drug action using electrochemical sensors
    Development and application of sensors selective to biologically active substances
    • 批准号:
      19590039
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.91万
    • 财政年份:
      2007
    • 负责人:
      KATSU Takashi
    • 依托单位:
    Development and application of high-performance ion-selective electrodes
    • 批准号:
      16590027
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.24万
    • 财政年份:
      2004
    • 负责人:
      KATSU Takashi
    • 依托单位:
    Development of drug electrodes with high sensitivity and selectivity
    • 批准号:
      10672019
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.24万
    • 财政年份:
      1998
    • 负责人:
      KATSU Takashi
    • 依托单位:
    海外基金