Studies on the role of nitric oxide in abnormal intestinal serotonin metabolism using a model rat of intestinal damage

采用抗肿瘤药物致肠道损伤模型大鼠，研究了一氧化氮（NO）在肠道血清素代谢异常中的作用。在所测试的四种药物中，甲氨蝶呤（MTX）特异性引起NO合成增加，从而诱导回肠肠嗜铬细胞增生和血清素合成增加。刺激肠道NO的产生与抗肿瘤药物的致吐性和促炎性无关。

The roles of nitric oxide (NO) in abnormal intestinal serotonin metabolism have been investigated using a model rat of intestinal damage induced by anti-cancer drugs. Among four drugs tested, methotrexate (MTX) specifically caused an increase in NO synthesis, which in turn induced a hyperplasia of ileal enterochromaffin cells and an increase in serotonin synthesis. The stimulation of intestinal NO production did not correlate with the emetogenicity and pro-inflammatory property of anti-cancer drugs.