Significance of feeding regulation of peptides in eating abnormality in digestive diseases

肽摄食调节在消化系统疾病饮食异常中的意义

• 批准号: 22590156
• 负责人: MIZUNO Shigeto
• 金额: $ 2.91万
• 依托单位: Kobe Pharmaceutical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22590156/
• 关键词: 消化器疾患; 摂食調節ペプチド; ヘリコバクター・ピロリ; 臨床疫学研究; インターフェロン; 摂量調節ペプチド

Helicobacter pylori is a bacterium that has infected more than half of the Japanese population and is associated with chronic gastritis, peptic ulcer, and gastric cancer. We conducted a clinical study on the association between Helicobacter pylori infection and various feeding and metabolic regulating factors. The result raises the possibility that Helicobacter pylori infection affects the host’s nutritional status through changes in the plasma levels of ghrelin, which regulates feeding behavior, and adiponectin, which regulates metabolic status.

幽门螺杆菌是一种细菌，感染了一半以上的日本人口，并与慢性胃炎，消化性溃疡和胃癌有关。我们对幽门螺杆菌感染与各种进食和代谢调节因素之间的关系进行了临床研究。该结果提出了幽门螺杆菌感染通过改变调节进食行为的ghrelin和调节代谢状态的脂联素的血浆水平来影响宿主营养状况的可能性。

项目成果

AP1B plays an important role in intestinal tumorigenesis with the truncating mutation of an APC gene

AP1B通过APC基因的截短突变在肠道肿瘤发生中发挥重要作用

• DOI: 10.1002/ijc.26131
• 发表时间: 2011
• 期刊: Int.J.Cancer
• 作者: Mimura;M.;et al
• 通讯作者: et al

Plasma ghrelin isoforms and gastric ghrelin O-acyltransferase expression are influenced by Helicobacter pylori status

• DOI: 10.1016/j.nut.2011.11.023
• 发表时间: 2012-10-01
• 期刊: NUTRITION
• 影响因子: 4.4
• 作者: Ando, Takashi;Mizuno, Shigeto;Inui, Akio
• 通讯作者: Inui, Akio

EFFECT OF GOAT OF THE STOMACH ON THE ACYLATION OF SERUM GHRELIN ACCORDING TO H. PYLORI STATUS IN HUMANS.

根据人类幽门螺杆菌状态，山羊胃对血清生长素释放肽酰化的影响。

• 发表时间: 2011
• 作者: Ando T;Ishida T;Mitsumoto Y;Imamoto E;Kishimoto E;Kato N;Okajima A;Suzuki T;Uchiyama K;Ishikawa T;Takagi T;Handa O;Yagi N;Kokura S;Naito Y;Yoshikawa T;TakeuchiM;Mizuno S;Asakawa A;Inui A.
• 通讯作者: Inui A.

胃内グレリン・GOAT発現および循環グレリン値に対するH.pylori感染の影響

幽门螺杆菌感染对胃 ghrelin/GOAT 表达和循环 ghrelin 水平的影响

• 发表时间: 2012
• 作者: Ishii K;Iizuka H;Ogaya T;Song Z;Fukushima T;安藤貴志,水野成人,乾明夫
• 通讯作者: 安藤貴志,水野成人,乾明夫

EFFECT OF GOAT OF THE STOMACH ON THE ACYLATION OF SERUM GHRELIN ACCORDING TO H.PYLORI STATUS IN HUMANS

根据人类幽门螺杆菌状态，山羊胃对血清生长素释放肽酰化的影响

• 发表时间: 2011
• 作者: Ando T;Ishida T;Mitsumoto Y;Imamoto E;Kishimoto E;Kato N;Okajima A;Suzuki T;Uchiyama K;Ishikawa T;Takagi T;Handa O;Yagi N;Kokura S;Naito Y;Yoshikawa T;TakeuchiM;Mizuno S;Asakawa A;Inui A.;Ando T
• 通讯作者: Ando T