Development of tetrahydrobiopterin-based therapy for neurological and cardiovascular disease

Pts-/- dps小鼠脑内生物terin含量低于野生型小鼠。野生型小鼠的大脑多巴胺含量随出生日期的增加而增加，而Pts-/- dps小鼠的大脑多巴胺含量则没有增加。Pts-/-小鼠脑内血清素含量降低P7。野生型小鼠脑内酪氨酸羟化酶蛋白含量随出生日期的增加而增加。相反，Pts-/- dps组的大脑则没有。Pts-/- dps小鼠大脑中苯丙氨酸含量在P0和P7之间显著增加。

Biopterin content in the brains of Pts-/-DPS mice was fewer than that of wild type mice. The amount of dopamine in the brains of wild type mice increased according to the date after birth, however, that of Pts-/-DPS mice did not. Serotonin content in the brains of Pts-/- mice decreased by P7. The amount of tyrosine hydroxylase protein in the brains of wild type mice increased according to the date after birth. On the contrary, that in the Pts-/-DPS brains did not. Phenylalanine content in the brains of Pts-/-DPS mice dramatically increased between P0 and P7.