Development of tetrahydrobiopterin-based therapy for neurological and cardiovascular disease
Development of tetrahydrobiopterin-based therapy for neurological and cardiovascular disease
批准号:
22590250
负责人:
SUMI-ICHINOSE Chiho
金额:
$2.83万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
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英文摘要
Biopterin content in the brains of Pts-/-DPS mice was fewer than that of wild type mice. The amount of dopamine in the brains of wild type mice increased according to the date after birth, however, that of Pts-/-DPS mice did not. Serotonin content in the brains of Pts-/- mice decreased by P7. The amount of tyrosine hydroxylase protein in the brains of wild type mice increased according to the date after birth. On the contrary, that in the Pts-/-DPS brains did not. Phenylalanine content in the brains of Pts-/-DPS mice dramatically increased between P0 and P7.
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シンポジウム 1 ビタミン研究の最前線
研讨会一 维生素研究前沿
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[一瀬宏, 本間大悟, 一瀬(鷲見)千穂, 近藤一直]
通讯作者:
近藤一直
DOI:
10.1074/jbc.m111.284729
发表时间:
2011-10
期刊:
The Journal of Biological Chemistry
影响因子:
--
作者:
[H. Tokuoka;S. Muramatsu;C. Sumi-Ichinose;Hiroaki Sakane;M. Kojima;Yoshinori Aso;T. Nomura;D. Met]
通讯作者:
H. Tokuoka;S. Muramatsu;C. Sumi-Ichinose;Hiroaki Sakane;M. Kojima;Yoshinori Aso;T. Nomura;D. Met
プテリン類の分析に関する 3 項目の検討
关于蝶呤分析的三项考虑
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[池本和久, 一瀬千穂, 野村隆英, 近藤一 直]
通讯作者:
近藤一 直
一瀬宏
一之濑浩
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Masuda T, et al., ビオプテリンによる脳内ドーパミン系の発達および神経機能との関連]
通讯作者:
ビオプテリンによる脳内ドーパミン系の発達および神経機能との関連
Recovery of neurogenic amines in phenylketonuria micefollowing liver-targeted gene therapy.
肝脏靶向基因治疗后苯丙酮尿症小鼠神经源性胺的恢复。
DOI:
--
发表时间:
2012
期刊:
Neuroreport
影响因子:
1.7
作者:
[Hiroya Yagi, Sho Sanechika, Sho Shimaguchi, Hiroshi Ichinose, Chiho Sumi-Ichinose, Hiroaki Mizukami, Masashi Urabe, Hiromi Hamada, Hiroyuki Yoshikawa,Keiya Ozawa, Akihiro Kume.]
通讯作者:
Akihiro Kume.
共 25 条
Tetrahydrobiopterin-deficiency causes hypertension with fluctuation, bradycardia and priapism.
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批准号:16K08561
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.24万
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财政年份:2016
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负责人:SUMI-ICHINOSE Chiho
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依托单位:
Developmental disturbance in model mice with abnormal pterin metabolism
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批准号:16590255
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.37万
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财政年份:2004
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负责人:SUMI-ICHINOSE Chiho
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依托单位:
海外基金