Study of mechanisms of repression of immune response at early stage of EHEC/EPEC infection

EHEC/EPEC感染早期免疫反应抑制机制研究

• 批准号: 22590389
• 负责人: TOBE Toru
• 金额: $ 2.83万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22590389/
• 关键词: 病原性; 病原性大腸菌; O157; 病原因子; 炎症応答; 157; III型エフェクター; アポトーシス; EPEC; III型分泌

By encountering pathogens hostcells induce inflammatory responses and activate immune responseto prevent infection of pathogens. Enterohaemorrhagic or enteropathogenic Escherichia coli (EHEC or EPEC) have ability to reduce these immune response at early stage of infection, and this ability could be important for successful infection.In this study, we identified several virulence factors involving suppression of inflammatory response and regulation of apoptosis in epithelial and immune cells.

通过遇到病原体宿主诱导炎症反应并激活免疫反应，可以防止病原体感染。肠ha虫或肠病性大肠杆菌（EHEC或EPEC）具有在感染早期阶段降低这些免疫反应的能力，并且这种能力对于成功的感染可能很重要。在这项研究中，我们确定了涉及抑制炎症反应和调节上皮细胞和免疫细胞肥中的毒力因子。

项目成果

Bifidobacteria can protect from enteropathogenic infection through production of acetate

• DOI: 10.1038/nature09646
• 发表时间: 2011-01-27
• 期刊: NATURE
• 影响因子: 64.8
• 作者: Fukuda, Shinji;Toh, Hidehiro;Ohno, Hiroshi
• 通讯作者: Ohno, Hiroshi

病原性大腸菌による宿主細胞の炎症応答調節機構

致病性大肠杆菌对宿主细胞炎症反应的调节

• 发表时间: 2013
• 作者: 顔宏哲;戸邉亨
• 通讯作者: 戸邉亨

Activation of Motility by Sensing Short-Chain Fatty Acids via Two Steps in a Flagellar Gene Regulatory Cascade in Enterohemorrhagic Escherichia coli

• DOI: 10.1128/iai.00927-10
• 发表时间: 2011-03-01
• 期刊: INFECTION AND IMMUNITY
• 影响因子: 3.1
• 作者: Tobe, Toru;Nakanishi, Noriko;Sugimoto, Nakaba
• 通讯作者: Sugimoto, Nakaba

Modulation of inflammatory response by Escherichia coli effectors

大肠杆菌效应子对炎症反应的调节

• 发表时间: 2011
• 作者: 顔宏哲;戸邉亨;戸邉亨
• 通讯作者: 戸邉亨