Study of mechanisms of repression of immune response at early stage of EHEC/EPEC infection

EHEC/EPEC感染早期免疫反应抑制机制研究

• 批准号: 22590389
• 负责人: TOBE Toru
• 金额: $ 2.83万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22590389/
• 关键词: 病原性; 病原性大腸菌; O157; 病原因子; 炎症応答; 157; III型エフェクター; アポトーシス; EPEC; III型分泌

By encountering pathogens hostcells induce inflammatory responses and activate immune responseto prevent infection of pathogens. Enterohaemorrhagic or enteropathogenic Escherichia coli (EHEC or EPEC) have ability to reduce these immune response at early stage of infection, and this ability could be important for successful infection.In this study, we identified several virulence factors involving suppression of inflammatory response and regulation of apoptosis in epithelial and immune cells.

宿主细胞通过与病原体的接触，诱导炎症反应，激活免疫反应，以防止病原体的感染.肠出血性或肠致病性大肠杆菌（Enterohemorrhagic or enteropathogenic Escherichia coli，EHEC或EPEC）在感染的早期就能降低这些免疫反应，这种能力对于感染的成功具有重要意义。

项目成果

Bifidobacteria can protect from enteropathogenic infection through production of acetate

• DOI: 10.1038/nature09646
• 发表时间: 2011-01-27
• 期刊: NATURE
• 影响因子: 64.8
• 作者: Fukuda, Shinji;Toh, Hidehiro;Ohno, Hiroshi
• 通讯作者: Ohno, Hiroshi

病原性大腸菌による宿主細胞の炎症応答調節機構

致病性大肠杆菌对宿主细胞炎症反应的调节

• 发表时间: 2013
• 作者: 顔宏哲;戸邉亨
• 通讯作者: 戸邉亨

Modulation of inflammatory response by Escherichia coli effectors

大肠杆菌效应子对炎症反应的调节

• 发表时间: 2011
• 作者: 顔宏哲;戸邉亨;戸邉亨
• 通讯作者: 戸邉亨

Activation of Motility by Sensing Short-Chain Fatty Acids via Two Steps in a Flagellar Gene Regulatory Cascade in Enterohemorrhagic Escherichia coli

• DOI: 10.1128/iai.00927-10
• 发表时间: 2011-03-01
• 期刊: INFECTION AND IMMUNITY
• 影响因子: 3.1
• 作者: Tobe, Toru;Nakanishi, Noriko;Sugimoto, Nakaba
• 通讯作者: Sugimoto, Nakaba