Trafficking of immune-competent cells mediated by high endothelial venule-associated cell trafficking signals and regulation of innate and acquired immune responses.

由高内皮微静脉相关细胞运输信号介导的免疫活性细胞的运输以及先天性和获得性免疫反应的调节。

• 批准号: 22590440
• 负责人: TANAKA Toshiyuki
• 金额: $ 2.91万
• 依托单位: Hyogo University of Health Sciences
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22590440/
• 关键词: 免疫学; 細胞動員; 血管内皮細胞; 自然免疫; 獲得免疫; 血管内細胞

Trafficking of immune-competent cell is crucial for efficient linkage between innate and adaptive immune responses. High endothelial venues (HEVs) recruit lymphocyte to lymph nodes, and express various tissue-specific cell trafficking signals. In this study, we found followings; 1) lymphocyte transmigration across the basal lamina of the HEVs is regulated, at least in part, by autotaxin (ATX) and its end-product, lysophosphatidic acid (LPA), 2) plasmacytoid dendritic cells employ both CCR7 and CXCR4 as critical chemokine receptors to migrate into the splenic white pulp under steady-state conditions, and 3) endothelial cells recognized regional inflammatory status and regulate expression of cell trafficking-associated molecules.

免疫活性细胞的运输对于先天性免疫反应和获得性免疫反应之间的有效联系至关重要。高内皮细胞场所(HEV)将淋巴细胞招募到淋巴结，并表达各种组织特异性细胞运输信号。在本研究中，我们发现：1)淋巴细胞在HEV基底层的迁移至少部分地受自体趋化蛋白(ATX)及其最终产物溶血磷脂酸(LPA)的调节，2)浆细胞样树突状细胞利用CCR7和CXCR4作为关键的趋化因子受体在稳态条件下迁移到脾白髓，以及3)内皮细胞识别局部炎症状态并调节细胞运输相关分子的表达。

项目成果

Constitutive pDC migration to the splenic white pulp is cooperatively regulated by CCR7 ligands and CXCL12

pDC 向脾白髓的组成性迁移由 CCR7 配体和 CXCL12 协同调节

• 发表时间: 2011
• 作者: Umemoto;E.;et al
• 通讯作者: et al

Nepmucin mediates uptake of apoptotic cells in the endothelial cells of high endothelial venules.

Nepmucin 介导高内皮微静脉的内皮细胞对凋亡细胞的摄取。

• 发表时间: 2010
• 作者: Umemoto;E.;Kunizawa;K.;Jin;S.,Yonekura;S.;Jang;M.H.;Tanaka;T;Miyasaka;M.
• 通讯作者: M.

Stem cell-like propertiesin CD133+ cells isolated from xenografted human malignant mesothelioma in immunodeficient mice.

从免疫缺陷小鼠异种移植的人类恶性间皮瘤中分离出的 CD133 细胞具有干细胞样特性。

• 发表时间: 2012
• 作者: Ohno Y;Tanaka T.
• 通讯作者: Tanaka T.

Constitutive pDC migration to the splenic white pulp is cooperatively regulated by CCR7 ligands and CXCL12.

pDC 向脾白髓的组成性迁移受到 CCR7 配体和 CXCL12 的协同调节。

• 发表时间: 2011
• 作者: Umemoto E;Ikeno T;Verjan Garcia N;Hayasaka H;Bai Z;Jang;M.H;Tanaka T;Miyasaka M.
• 通讯作者: Miyasaka M.

Natural killer cells target HCV core proteins during the innate immune response in HCV transgenic mice

• DOI: 10.1002/jmv.21859
• 发表时间: 2010-09
• 期刊: Journal of Medical Virology
• 影响因子: 12.7
• 作者: Kenichi Satoh;Hiroki Takahashi;C. Matsuda;Toshiyuki Tanaka;M. Miyasaka;M. Zeniya;M. Kohara