Trafficking of immune-competent cells mediated by high endothelial venule-associated cell trafficking signals and regulation of innate and acquired immune responses.

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Trafficking of immune-competent cell is crucial for efficient linkage between innate and adaptive immune responses. High endothelial venues (HEVs) recruit lymphocyte to lymph nodes, and express various tissue-specific cell trafficking signals. In this study, we found followings; 1) lymphocyte transmigration across the basal lamina of the HEVs is regulated, at least in part, by autotaxin (ATX) and its end-product, lysophosphatidic acid (LPA), 2) plasmacytoid dendritic cells employ both CCR7 and CXCR4 as critical chemokine receptors to migrate into the splenic white pulp under steady-state conditions, and 3) endothelial cells recognized regional inflammatory status and regulate expression of cell trafficking-associated molecules.