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Comprehensive study to elucidate molecular mechanisms behind intrahepatic cholestasis

Comprehensive study to elucidate molecular mechanisms behind intrahepatic cholestasis
综合研究阐明肝内胆汁淤积背后的分子机制
批准号:
22590746
负责人:
KAGAWA Tatehiro
金额:
$2.5万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012

项目摘要

项目成果

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中文摘要
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英文摘要
Intrahepatic cholestasis is a difficult-to-treat disease. Although ursodeoxycholic acid has choleretic effect and is widely used to treat cholestasis, molecular mechanisms behind this effect remain unknown. In this study we demonstrated that ursodeoxycholic acid induces choleresis by stabilizing bile salt export pump in the apical membrane.
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会议论文
UDCAによるbile salt export pump活性化機序の解析
UDCA激活胆盐输出泵机制分析
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [宮田昌明, 畑竜也, 加川建弘, 加川建弘]
通讯作者: 加川建弘
DOI: 10.2214/ajr.11.7002
发表时间: 2012-07-01
期刊: AMERICAN JOURNAL OF ROENTGENOLOGY
影响因子: 5
作者: [Koizumi, Jun, Hashimoto, Takeshi, d'Othee, Bertrand Janne]
通讯作者: d'Othee, Bertrand Janne
Partial splenic embolization using n-butyl cyanoacrylate: intraprocedural evaluation by magnetic resonance imaging
使用氰基丙烯酸正丁酯进行部分脾栓塞:通过磁共振成像进行术中评估
DOI: --
发表时间: 2013
期刊: Eur Radiol
影响因子: 5.9
作者: [Koizumi J, Kagawa T, et al]
通讯作者: et al
Carbon dioxide (CO2) vs iodinated contrast digital subtraction angiography during balloon-occluded retrograde transvenous obliteration (BRTO) using foam sclerosant for gastric varices.
使用泡沫硬化剂治疗胃静脉曲张的球囊闭塞逆行经静脉闭塞术 (BRTO) 期间二氧化碳 (CO2) 与碘对比数字减影血管造影。
DOI: --
发表时间: 2012
期刊: Journal of Vascular and Interventional Radiology
影响因子: 2.9
作者: [J. Koizumi, Takeshi Hashimoto, K. Myojin, Chihiro Itou, T. Hara, T. Sekiguchi, T. Ichikawa, Y. Imai, T. Kagawa, N. Nagata, N. Watanabe, T. Mine, T. Nishibe, T. Saguchi, B. J. Janne d'Othée]
通讯作者: B. J. Janne d'Othée
27
    Impact of butyrate-producing bacteria in the gut on fatty liver diseases.
    • 批准号:
      18K11002
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.83万
    • 财政年份:
      2018
    • 负责人:
      KAGAWA Tatehiro
    • 依托单位:
    Mechanisms of intrahepatic cholestasis and biochemical analysis of bile salt export pump(ABCB 11)
    • 批准号:
      17590681
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.31万
    • 财政年份:
      2005
    • 负责人:
      KAGAWA Tatehiro
    • 依托单位:
    INTRACELLULAR TRAFFICKING MECHANISM OF TRANSPORTERS LOCATED ALONG THE CANALICULAR MEMBRANE OF HEPATOCYTES
    • 批准号:
      10670508
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.11万
    • 财政年份:
      1998
    • 负责人:
      KAGAWA Tatehiro
    • 依托单位:
    Anti-proliferative effect of K-ras antisense oligodeoxynucleotides on pancreatic cancer cell line
    • 批准号:
      08670627
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $1.41万
    • 财政年份:
      1996
    • 负责人:
      KAGAWA Tatehiro
    • 依托单位:
    海外基金