Significance of the interaction between antizyme 2 and CDR2 under hypoxia in cancer cells

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c-mycis known as the most famous oncogene and encodes c-MYC oncoprotein. c-MYC contributes to cell proliferation, ribosomal biosynthesis, glycolysis and apoptosis. It has been reported that regulation of c-MYC degradation is mediated by ubiquitin-proteasome pathway. However wefound that antizyme 2 protein which regulates cellular polyamine level accelerates degradation of c-MYC by the proteasome ubiquitin-independently. In this study, weshowed that novel ubiquitin independent c-MYC degradation pathway exist in the cells.