Analysis of estrogen signaling specific and/or common to brainfunction and cancer, and its clinical relevance

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Estrogen plays important roles in brain function and breast cancer. In this study, I aimed to explore the novel estrogen-responsive genes in brain and cancer tissues for identifying specific and/or common estrogen signaling pathway between these tissues. In addition to estrogen-responsive genes that we have previously reported, clinical relevance of these estrogen-responsive genes is also explored. We identified novelestrogen-responsive genes specific in hippocampus, hypothalamus and brain stem. These novel estrogen-responsive genes are known to be associated with breast cancer. We also demonstrated that the expression of transcription factors, FOXA1 and FOXP1 is induced by estrogen in breast cancer cells and immunoreactivities of FOXA1 and FOXP1 are positively correlated with good prognosis of breast cancer patients with tamoxifen treatment. These findings would uncover novel role of estrogen signaling in brain function and cancers.