Application of humanized mice to analyses and therapeutics of phagocytic disorders

遗传改良的老鼠的用途被发现对疾病病理学中的测试有显著的益处。在这项研究中，CD 34细胞从患有多个并发症的患者中纯化的骨头marrow细胞被注射到NOD/SCID/·cnull（NOG）老鼠内部。The human cells engrafted in mice showed the maturation arrest of myeloid cells as well as the absence of mature human neutrophils. These Results Suggest that the establishment of humanized mice may significantly to analyses of pathophysiology and therapeutic approach in patients with SCN.

The use of genetically modified mice has led to significant advantages for the examination of in disease pathophysiology. In this study, CD34 cells purified from bone marrow in patients with severe congenital neutropenia were injected to NOD/SCID/・cnull(NOG) mice intravenously. The human cells engrafted in mice showed the maturation arrest of myeloid cells as well as the absence of mature human neutrophils. These results suggest that the establishment of humanized mice may significantly contribute to analyses of pathophysiology and therapeutic approach in patients with SCN.