Evaluation and therapeutic application of lymphangiogenesis using animal model with lymph node metastasis of lung neoplasm

我们已经探索了发挥淋巴管生成抑制剂作用的种子，并评估了库中80个系列的药物。结果表明，紫草素对淋巴管生成有较强的抑制作用，这种抑制作用是通过增加与细胞外基质的粘附而不是通过淋巴管内皮细胞的迁移来实现的。另一方面，作为紫草素衍生物的脱氧紫草素产生相反的反应以增加淋巴管的血管生成。

We have explored seeds that played the role of lymphangiogenetic inhibitor and evaluated 80 series of agents in the library. As a result, Shikonin had a strong inhibitory effect to lymphangiogenesis, and this affection was introduced by increasing of adhesion to some extracellular matrix, and is not by migration of lymphatic endocell. On the other hand, Deoxyshikonin which is a derivative from Shikonin, made an opposite reaction to increase an angiogenesis of lymphatic vessels.