The role of novel extracellular matrix protein on CNS regeneration and its application study for glaucoma treatment

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In our strategies toward optic nerve regeneration of mammals using fish derived molecule, we used purpurin(a novel extracellular matrix protein) overexpression systems by adeno-associated virus vector in rat retina. In rat, supply of purpurin could protect retinal ganglion cells(RGCs) from injury-induced apoptosis through a mechanism of focal adhesion kinase(FAK)/Akt activation. Furthermore, purpurin had adhesive effect on rat RGCs from culture study with purpurin-coated dishes. We focused on the extracellular matrix-related molecules as a mechanism of purpurin adhesive and survival effects. Purpurin inhibited optic injury-induced matrix metalloprotease 9 activity and the degradation of laminin and activated FAK signaling. Purpurin could potentially offer new avenues for developing treatments for human retinal degenerative disorders such as glaucoma.