Mechanism of decreased tear secretion in mice with metabolic syndrome

我们证明，高脂饮食喂养的代谢综合征模型小鼠的泪液体积显著减少。高脂饲料组大鼠泪腺炎性细胞浸润和炎症相关基因表达水平明显增加。高脂组泪腺8-OHdG免疫组织化学染色阳性。代谢综合征影响小鼠的泪腺功能，这可能是由氧化损伤和随后的腺体炎症引起的。

We demonstrated that tear volume significantly decreased in metabolic syndrome model mice fed with a high fat diet. Inflammatory cell infiltration and inflammatory related gene expression level in the lacrimal glands were significantly increased in the high fat fed group. Immunohistochemistry of the lacrimal glands showed positive staining for 8-OHdG in the high fat group. Metabolic syndrome influences lacrimal gland function in mice, which might be caused by oxidative damage and the subsequent gland inflammation.