Bone regeneration using autologous fibrin gel with adipose derived stem cells

使用自体纤维蛋白凝胶和脂肪干细胞进行骨再生

• 批准号: 22791930
• 负责人: TAJIMA Nobutaka
• 金额: $ 2.33万
• 依托单位: Nagasaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22791930/
• 关键词: 脂肪由来幹細胞; フィブリン; 骨再生; PRF; インプラント

Adipose derived stem cells(ADSCs), which have high proliferation potency and pluripotency, can be extracted from adipose tissue. The purpose of this study was to develop a bone regeneration using ADSCs and fibrin gel. When ADSCs were cultured in osteogenic medium without BMP-2, differentiation of ADSCs into osteoblastic cells was not sufficient. On the other hand, bone regeneration was seen when autologous fibrin gel was grafted into a closed cavity such as sinus making a space for bone regeneration.

脂肪源性干细胞（Adipose derived stem cells，ADSCs）是从脂肪组织中提取的具有高增殖能力和多能性的细胞。本研究的目的是开发一种使用脂肪干细胞和纤维蛋白凝胶的骨再生。当ADSC在无BMP-2的成骨培养基中培养时，ADSC分化为成骨细胞是不充分的。另一方面，当自体纤维蛋白凝胶移植到封闭的腔体如窦中时，观察到骨再生，从而为骨再生提供空间。

项目成果

Evaluation of Sinus Floor Augmentation with Simultaneous Implant Placement Using Platelet-Rich Fibrin as Sole Grafting Material

• DOI: 10.11607/jomi.2613
• 发表时间: 2013-01-01
• 期刊: INTERNATIONAL JOURNAL OF ORAL & MAXILLOFACIAL IMPLANTS
• 影响因子: 2
• 作者: Tajima, Nobutaka;Ohba, Seigo;Asahina, Izumi
• 通讯作者: Asahina, Izumi