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Economical and Efficient Production of Cardiac Myocytes Using Small Molecule-Responsive Artificial Receptors For Wnt3a Signal Transduction

Economical and Efficient Production of Cardiac Myocytes Using Small Molecule-Responsive Artificial Receptors For Wnt3a Signal Transduction
使用小分子反应性人工受体进行 Wnt3a 信号转导,经济高效地生产心肌细胞
批准号:
22760607
负责人:
SOGO Takahiro
金额:
$2.66万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2011

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中文摘要
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英文摘要
We constructed chimeric receptors in which single-chain Fv of anti-fluorescein(FL) antibody was tethered to transmembrane/cytoplasmic domains of Frizzled8 and LRP6 that are receptors for Wnt3a. Mouse ES cells or iPS cells transduced with these chimeric receptors could activate Wnt3a signaling in response to FL-conjugated BSA(BSA-FL) as a cognate ligand, and could efficiently differentiate into cardiomyocyte when they are stimulated with BSA-FL, in the absence of Wnt3a.
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Efficient Production of Cardiac Myocytes from ES cells and iPS cells Using Small Molecule-responsive Artificial Receptors for Wnt3a Signal Transduction
使用小分子反应性人工受体进行 Wnt3a 信号转导,从 ES 细胞和 iPS 细胞高效生产心肌细胞
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Sogo T, Kawamura T]
通讯作者: Kawamura T
Efficient creation of induced pluripotent stem cells for myocardial regeneration therapy.
有效创建用于心肌再生治疗的诱导多能干细胞。
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Sogo T, Takaya T, Shigeno A, Kojima Y, Hasegawa K, Kawamura T.]
通讯作者: Kawamura T.
Role of Wnt signaling in cardiac differentiation from mouse embryonic stem cells and induced pluripotent stem cells.
Wnt 信号在小鼠胚胎干细胞和诱导多能干细胞心脏分化中的作用。
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Shigeno A, Sogo T, Takaya T, Kojima Y, Hasegawa K, Kawamura T.]
通讯作者: Kawamura T.
アンチ・エイジング医学-日本抗加齢医学会雑誌
抗衰老医学 - 日本抗衰老医学会杂志
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [Sato N, Sakata H, Tanaka Y, Taira M, 大隅典子]
通讯作者: 大隅典子
9
    Regulation and analysis of Wnt signaling using artificial receptors for regenerative medicine
    海外基金