Fish mucosal chemokines

本课题从河豚鱼中分离到两种粘膜趋化因子，其中一种在皮肤、鳃和胸腺中表达，原位杂交结果显示，皮肤表皮细胞表达该趋化因子。这种表达模式与皮肤白细胞的定位一致。这种趋化因子的假定受体在相同的器官中表达。第二种粘膜趋化因子及其受体在河豚的皮肤、鳃、胸腺和肠中均有表达。这些粘膜趋化因子在鱼类皮肤粘膜免疫系统中起着关键作用。

In this project, two fugu mucosal chemokines were identified, One of them was expressed in the skin, gills and thymus of fugu In the skin, in situ hybridization revealed that the fugu epidermal cells expressed this chemokine. This expression pattern was consistent with the localization of the skin leukocytes. A putative receptor for this chemokine was expressed in the same organs. The second mucosal chemokine and its putative receptor were expressed in the skin, gills, thymus, and intestine of fugu. These mucosal chemokines would play pivotal roles in the fish mucosal skin immune system.