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Analysis on molecular mechanisms of proliferation and differentiation of hepatic stem/progenitor cells and development of animal model for treatment of liver diseases using hepatic stem cells

Analysis on molecular mechanisms of proliferation and differentiation of hepatic stem/progenitor cells and development of animal model for treatment of liver diseases using hepatic stem cells
肝干/祖细胞增殖分化的分子机制分析及肝干细胞治疗肝病动物模型的建立
批准号:
22790632
负责人:
KAKINUMA Sei
金额:
$2.5万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2011

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项目成果

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中文摘要
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英文摘要
Investigators of this research project have analyzed on the molecular mechanisms of differentiation and proliferation of primary hepatic stem/progenitor cells purified by cell surface markers. We have also studied whether modulation of several molecules improves therapeutic efficacy of transplantation using hepatic stem/progenitor cells. We found that Wnt5a and Wnt5a-related molecules control the biliary differentiation of hepatic stem/progenitor cells. Next, our data indicated that loss of MMP2 or MMP14 worsens the efficacy of transplantation using hepatic stem/progenitor cells. These studies contribute to the progress of regenerative medical science and autologous stem cell therapy against liver diseases.
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会议论文
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Kakinuma S, Kamiya A, Sakamoto N, Watanabe M, Nakauchi H.]
通讯作者: Nakauchi H.
Noncanonical Wnt経路による肝幹/前駆細胞の分化制御
非经典 Wnt 通路调控肝干/祖细胞分化
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [幾世橋佳, 柿沼晴, 渡辺守]
通讯作者: 渡辺守
MMP-2 and MMP-14 derived from donor cells enhance therapeutic efficacy of liver cell transplantation in mice
供体细胞来源的 MMP-2 和 MMP-14 增强小鼠肝细胞移植的治疗效果
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Kakinuma S, Sakamoto N, Watanabe M, et al.]
通讯作者: et al.
DOI: 10.1016/j.virol.2010.07.041
发表时间: 2010-11
期刊: Virology
影响因子: 3.7
作者: [G. Suda;N. Sakamoto;Yasuhiro Itsui;M. Nakagawa;Megumi Tasaka-Fujita;Yusuke Funaoka;Takako Watanabe;S. Nitta;Kei Kiyohashi;Seishin Azuma;S. Kakinuma;K. Tsuchiya;M. Imamura;N. Hiraga;K. Chayama;Mamoru Watanabe]
通讯作者: G. Suda;N. Sakamoto;Yasuhiro Itsui;M. Nakagawa;Megumi Tasaka-Fujita;Yusuke Funaoka;Takako Watanabe;S. Nitta;Kei Kiyohashi;Seishin Azuma;S. Kakinuma;K. Tsuchiya;M. Imamura;N. Hiraga;K. Chayama;Mamoru Watanabe
34
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    • 批准号:
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