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Analyses of molecular mechanisms underlying differentiation and proliferation of hepatic stem/progenitor cells for development of novel cell transplantation models

Analyses of molecular mechanisms underlying differentiation and proliferation of hepatic stem/progenitor cells for development of novel cell transplantation models
分析肝干/祖细胞分化和增殖的分子机制,用于开发新型细胞移植模型
批准号:
15K08988
负责人:
KAKINUMA Sei
金额:
$3.08万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2015
资助国家:
日本
项目状态:
已结题
起止时间:
2015-04-01 至 2018-03-31

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中文摘要
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期刊论文(9)
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科研奖励(0)
会议论文
Human induced pluripotent stem cell-derived hepatic progenitor-like cells and hepatocyte-like cells as a model for interaction between hepatitis B virus and host cells.
人类诱导多能干细胞来源的肝祖细胞样细胞和肝细胞样细胞作为乙型肝炎病毒与宿主细胞之间相互作用的模型。
DOI: --
发表时间: 2015
期刊:
影响因子: --
作者: [Kaneko S, Kakinuma S, Asahina Y, Kamiya A, Nitta S, Tsunoda T, Miyoshi M, Nagata H, Goto F, Otani S, Murakawa M, Kawai-Kitahata F, Itsui Y, Nakagawa M, Azuma S, Watanabe M.]
通讯作者: Watanabe M.
A novel culture model for coinfection of hepatitis B and hepatitis C viruses using human induced pluripotent stem cell-derived hepatic cells for analyses of changes in host-innate immune responses.
乙型肝炎和丙型肝炎病毒共感染的新型培养模型,使用人诱导多能干细胞衍生的肝细胞来分析宿主先天免疫反应的变化。
DOI: --
发表时间: 2017
期刊:
影响因子: --
作者: [Kaneko S, Kakinuma S, Asahina Y, Kamiya A, Miyoshi M, Tsunoda T, Inoue-Shinomiya E, Nitta S, Sato A, Asano Y, Nagata H, Kawai-Kitahata F, Murakawa M, Itsui Y, Nakagawa M, Azuma S, Watanabe M.]
通讯作者: Watanabe M.
ゲノム編集ヒトiPS 細胞による疾患モデルを用いた先天性肝線維症の病態メカニズムの解析
利用基因组编辑的人类 iPS 细胞的疾病模型分析先天性肝纤维化的病理机制
DOI: --
发表时间: 2017
期刊:
影响因子: --
作者: [角田知之, 柿沼 晴, 渡辺 守]
通讯作者: 渡辺 守
ITPA gene variation and ribavirin-induced anemia in patients with genotype 2 chronic hepatitis C treated with sofosbuvir plus ribavirin.
使用索磷布韦加利巴韦林治疗的基因型 2 慢性丙型肝炎患者的 ITPA 基因变异和利巴韦林诱发的贫血。
DOI: 10.1111/hepr.12867
发表时间: 2017
期刊: Hepatol Res
影响因子: 4.2
作者: [Murakawa M, Asahina Y, Nagata H, Nakagawa M, Kakinuma S, Nitta S, Kawai-Kitahata F, Otani S, Kaneko S, Miyoshi M, Tsunoda T, Asano Y, Sato A, Itsui Y, Azuma S, Nouchi T, Furumoto Y, Asano T, Chuganji Y, Tohda S, Watanabe M.]
通讯作者: Watanabe M.
6
    Development of human iPS cell-derived liver organoids for the discovery of target molecules for a therapy of liver fibrosis
    • 批准号:
      18H02790
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $10.98万
    • 财政年份:
      2018
    • 负责人:
      KAKINUMA Sei
    • 依托单位:
    Studies on molecular mechanisms regulating fate decision of hepatic stem cells and efficacy of hepatic stem cell transplantation
    • 批准号:
      24590957
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.33万
    • 财政年份:
      2012
    • 负责人:
      KAKINUMA Sei
    • 依托单位:
    Analysis on molecular mechanisms of proliferation and differentiation of hepatic stem/progenitor cells and development of animal model for treatment of liver diseases using hepatic stem cells
    • 批准号:
      22790632
    • 项目类别:
      Grant-in-Aid for Young Scientists (B)
    • 资助金额:
      $2.5万
    • 财政年份:
      2010
    • 负责人:
      KAKINUMA Sei
    • 依托单位:
    Research on molecular mechanism of hepatic stem cell proliferation and development of mouse models for stem cell transplantation
    • 批准号:
      20790485
    • 项目类别:
      Grant-in-Aid for Young Scientists (B)
    • 资助金额:
      $2.75万
    • 财政年份:
      2008
    • 负责人:
      KAKINUMA Sei
    • 依托单位:
    海外基金