Chemoprevention for gastric carcinogenesis by inhibition of renin-angiotensin system

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Gastric mucosal AT1R and AT2R mRNAs/β-actin mRNA ratios were approximately zero in H. pylori uninfected animals throughout the 12-month observation period. On the other hand, both AT1R and AT2R mRNA ratios in animals treated with wild-type H. pylori gradually increased during the time course. The median MNCs infiltration score was significantly correlated with AT1R and AT2R levels. The cagA-and oipA-knockout strain induced significantly milder inflammation compared with the wild-type. AT1R and AT2R mRNA levels were significantly higher in gerbils that developed gastric ulcers than in gerbils without gastric ulcer, suggested that RAS inhibitors may have chemoprevention for gastric carcinogenesis.