Elucidation of a new mechanism of the cardiovascular pathologies by novel physiologically activity substance identified by proteomic analysis

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Cardiovascular diseases are main diseases to occupy the high rank of the cause of death in the developed nations including our country. The cardiovascular system maintains homeostasis through the control with the peptide-related bioactive substance and presents with the condition of a pathology onset at the time of the failure. In late years proteomics analysis particularlythe technological change of the mass spectrometer allowed high sensitivity measurement of a very small amount of protein. Diagnostic usefulness as the biomarkerwas shown by assuming a cardiovascular disease-specific bioactive substance a target in this study, and analyzing the condition of a patient in the coronary disease condition of a patient.