Histochemical and neurochemical studies on the biological basis of orofacial neuropathic pain

口腔外科手术后三叉神经损伤会引起口面部的神经性疼痛。本课题研究了大鼠口面神经病理性疼痛的两种机制。我们分析了蛋白激酶Cγ的作用和三叉神经脊束核尾侧亚核星形胶质细胞谷氨酰胺合成酶活性在实验诱导的神经病理性疼痛中的可能贡献。我们还研究了多巴胺能活性的调节机制方面的延髓核，因为疼痛的事件，如三叉神经损伤，已知强烈影响多巴胺能活性在这方面。

Trigeminal nerve injury following oral surgery is known to elicit neuropathic pain in the orofacial region. In this project, we studied two mechanisms of orofacial neuropathic pain in rats. We analysed the role of protein kinase Cγ and the possible contribution of astroglial glutamine synthetase activity in the trigeminal spinal subnucleus caudalis to the experimentally-induced neuropathic pain. We also investigated aspects of the mechanisms of the regulation of dopaminergic activity in the nucleus accumbens, because painful events such as trigeminal nerve injury are known to strongly affect the dopaminergic activity in this area.