Histochemical and neurochemical studies on the biological basis of orofacial neuropathic pain

众所周知，口腔手术后的三叉神经损伤会在口面部引起神经病理性疼痛。在本课题中，我们研究了大鼠口腔面神经病理性疼痛的两种机制。我们分析了蛋白激酶Cγ的作用以及三叉神经脊束核尾侧亚核星形胶质细胞谷氨酰胺合成酶活性在实验性神经病理性疼痛中的可能作用。我们还研究了伏隔核多巴胺能活动的调节机制，因为已知三叉神经损伤等疼痛事件强烈影响该区域的多巴胺能活动。

Trigeminal nerve injury following oral surgery is known to elicit neuropathic pain in the orofacial region. In this project, we studied two mechanisms of orofacial neuropathic pain in rats. We analysed the role of protein kinase Cγ and the possible contribution of astroglial glutamine synthetase activity in the trigeminal spinal subnucleus caudalis to the experimentally-induced neuropathic pain. We also investigated aspects of the mechanisms of the regulation of dopaminergic activity in the nucleus accumbens, because painful events such as trigeminal nerve injury are known to strongly affect the dopaminergic activity in this area.