The function of PKR in differentiation of mesenchymal stem cells.

PKR在骨髓间充质干细胞分化中的作用尚不清楚。我们的研究表明，PKR调控软骨细胞和破骨细胞的分化。PKR的表达反映了肠上皮细胞和胃癌细胞的分化阶段。这些结果表明，PKR在骨髓间充质干细胞分化过程中起重要作用。这些发现将有助于更好地了解骨和软骨相关疾病，并发现治疗靶点。

An involvement of PKR in differentiation of mesenchymal stem cells has not been clarified yet. Our studies revealed that PKR regulated the differentiation of chondrocyte and osteoclast. The PKR expression reflected the differentiational stage of intestinal epithelial cells and stomach cancer cells. These results indicated that PKR played an important role on the differentiation of mesenchymal stem cells. The findings will contribute to better understanding of bone and cartilage associated disease and a discovery of therapeutic target.