The effect of chlorhexidine to improve dentin bond durability

氯己定改善牙本质粘结耐久性的作用

• 批准号: 22592114
• 负责人: HIRAISHI Noriko
• 金额: $ 2.83万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010-04-01 至 2013-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22592114/
• 关键词: クロルヘキシジン; 歯科材料; 象牙質; 親水性; 接着歯学; レジン; 抗菌作用; ＭＭＰｓ; 接着強さ; MMAレジンセメント; Self-etch接着システム; 抗菌性; pH cycling法; 根面う蝕

I studied the effect of chlorhexidine incorporation into experimental dentin adhesives with different hydrophilicities on the chlorhexidine release and the microtensile bond strength to dentin after 24 h and 14 months after specimen preparation. The more chlorhexidine released the more hydrophilic resin co-monomers. Significant reduction in bond strength was observed in all adhesive groups, except for chlorhexidine-containing most hydrophobic adhesive. Also, MMA-based resin was used to measure chlorhexidine-release from resin cement by means of HPLC, and antibacterial effect against Streptococcus mutans and Enterococcus faecalis. The 3.0 and 4.0% chlorhexidine-incorporated cement exhibited chlorhexidine release for 5 weeks; however, more than 98% of chlorhexidine was retained in resin matrix. The 3.0 and 4.0% chlorhexidine-incorporated resin cement possessed prolonged chlorhexidine release and antibacterial properties for 2 weeks.

我研究了氯己定掺入实验牙本质粘合剂与不同的结晶度的氯己定释放和微拉伸粘结强度的牙本质标本制备后24小时和14个月后的效果。释放的氯己定越多，亲水性树脂共聚单体越多。在所有粘合剂组中观察到粘合强度显著降低，但含氯己定的最疏水粘合剂除外。此外，MMA为基础的树脂被用来衡量洗必泰从树脂水泥通过HPLC释放，并对变形链球菌和粪肠球菌的抗菌效果。 3.0和4.0%氯己定骨水泥显示氯己定释放5周;然而，超过98%的氯己定保留在树脂基质中。含3.0和4.0%洗必泰的树脂骨水泥具有2周的洗必泰缓释和抗菌性能。

项目成果

Effect of Hesperidin on Collagen and Demineralization in Root Dentin.

橙皮苷对根部牙本质胶原蛋白和脱矿质的影响。

• 发表时间: 2011
• 作者: Hiraishi N;et al.
• 通讯作者: et al.

Effect of natural cross-linkers incorporation in a self-etching primer on dentine bond strength

• DOI: 10.1016/j.jdent.2012.08.015
• 发表时间: 2012-12-01
• 期刊: JOURNAL OF DENTISTRY
• 影响因子: 4.4
• 作者: Islam, Sofiqul;Hiraishi, Noriko;Tagami, Junji
• 通讯作者: Tagami, Junji

Glutathione Detoxification of 2-hydroxyethylmethacrylate and Its Effect on Bond Strength

甲基丙烯酸2-羟乙酯的谷胱甘肽解毒及其对粘合强度的影响

• 发表时间: 2013
• 作者: Nassar Mohannad;Hiraishi Noriko;Islam Md.Sofiqul;Yukihiko Tamurad;Masayuki Otsukia;Shohei Kasugaie;Keiichi Ohyad;Junji Tagamia;Tay Flanklin
• 通讯作者: Tay Flanklin

Chlorhexidine release and antibacterial properties of chlorhexidine-incorporated polymethyl methacrylate-based resin cement

• DOI: 10.1002/jbm.b.31633
• 发表时间: 2010-07-01
• 期刊: JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
• 影响因子: 3.4
• 作者: Hiraishi, N.;Yiu, C. K. Y.;Tay, F. R.
• 通讯作者: Tay, F. R.

Effect of chlorhexidine incorporation into a self-etching primer on dentine bond strength of a luting cement

• DOI: 10.1016/j.jdent.2010.03.005
• 发表时间: 2010-06-01
• 期刊: JOURNAL OF DENTISTRY
• 影响因子: 4.4
• 作者: Hiraishi, N.;Yiu, C. K. Y.;Tay, F. R.
• 通讯作者: Tay, F. R.