The effect of chlorhexidine to improve dentin bond durability

我研究了将氯己定掺入不同亲水性的实验性牙本质胶粘剂中，在试样制备后24 h和14个月对氯己定释放量和与牙本质的微拉伸结合强度的影响。氯己定释放越多，亲水树脂共单体越多。除含有氯己定的大多数疏水胶粘剂外，所有胶粘剂组的粘接强度均显著降低。同时，采用高效液相色谱法测定树脂水泥中氯己定的释放量，以及对变形链球菌和粪肠球菌的抑菌效果。3.0%和4.0%氯己定掺入水泥的氯己定释放时间为5周；而氯己定在树脂基质中保留了98%以上。含3.0%和4.0%氯己定的树脂水泥具有较长的氯己定释放时间和2周的抗菌性能。

I studied the effect of chlorhexidine incorporation into experimental dentin adhesives with different hydrophilicities on the chlorhexidine release and the microtensile bond strength to dentin after 24 h and 14 months after specimen preparation. The more chlorhexidine released the more hydrophilic resin co-monomers. Significant reduction in bond strength was observed in all adhesive groups, except for chlorhexidine-containing most hydrophobic adhesive. Also, MMA-based resin was used to measure chlorhexidine-release from resin cement by means of HPLC, and antibacterial effect against Streptococcus mutans and Enterococcus faecalis. The 3.0 and 4.0% chlorhexidine-incorporated cement exhibited chlorhexidine release for 5 weeks; however, more than 98% of chlorhexidine was retained in resin matrix. The 3.0 and 4.0% chlorhexidine-incorporated resin cement possessed prolonged chlorhexidine release and antibacterial properties for 2 weeks.