Analysis of microRNA in temporomandibular joint inflammation

颞下颌关节炎症中的microRNA分析

• 批准号: 22592230
• 负责人: KONDOH Toshirou
• 金额: $ 2.83万
• 依托单位: Nihon University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22592230/
• 关键词: 顎関節; 滑膜炎; 滑膜細胞; microRNA; マイクロアレイ解析; interluekin-1β; tumor necrosis factor-α; 顎関節内障; 顎関節滑膜細胞; mRNA; microRNA標的遺伝子; IL-1beta; TNF-arpha; interleukin-1; tumor necrosis factor; TargetScan; microRNA標的遺伝

MicroRNA (miRNA) are a class of small non-coding RNAs that mediate the post-transcriptional regulation of target mRNA expression. miRNA are associated with pathologic conditions. We have investigated of IL-1β or TNF-α-responsive miRNA and mRNA in synoviocytes for putative genes associated with the synovitis using microarray analysis. The target genes for IL-1β? and/or TNF-α?responsive miRNA were searched by the databases such as TargetScan. The expressions of the target genes were analyzed by DNA microarray. The knowledge of miRNA-miRNA studies would help to understand the pathologic conditions in TMJ.

microRNA（miRNA）是一类小型非编码RNA，介导靶mRNA表达的转录后调节。 miRNA与病理条件有关。我们已经使用微阵列分析研究了与滑膜炎相关的滑膜炎的IL-1β或TNF-α反应miRNA和mRNA。 IL-1β的靶基因？和/或TNF-α？响应性miRNA由数据库（例如TargetScan）搜索。通过DNA微阵列分析了靶基因的表达。 miRNA-miRNA研究的知识将有助于理解TMJ中的病理状况。

项目成果

顎関節疾患への低侵襲手術と拡大手術

颞下颌关节病的微创手术和扩大手术

• 作者: 河島睦;他;伊藤耕他4名;Toshirou Kondoh;河島 睦;近藤壽郎
• 通讯作者: 近藤壽郎

IL-1β刺激滑膜細胞におけるCOX阻害薬の効果

COX 抑制剂对 IL-1β 刺激的滑膜细胞的影响

• 发表时间: 2012
• 作者: Ogura N;Takahashi K;Iwai S;Fujimoto Y;Hashimoto H;Kondoh T.;河島 睦;河島睦,小倉直美,阿久津美和,伊藤耕,近藤壽郎;Toshirou Kondoh.;河島睦他4名
• 通讯作者: 河島睦他4名

The anti-inflammatory effect of cyclooxygenase inhibitors in fibroblast-like synoviocytes from the human temporomandibular joint results from the suppression of PGE2 production.

• DOI: 10.1111/jop.12045
• 发表时间: 2013-07
• 期刊: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
• 作者: Kawashima M;Ogura N;Akutsu M;Ito K;Kondoh T
• 通讯作者: Kondoh T

Predictive factors of temporomandibular joint disease in synovial tissues and fluid---A microarray analysis of synovial cells and a literature search on synovial fluid analysis

滑膜组织和液体中颞下颌关节病的预测因素--滑膜细胞的微阵列分析和滑液分析的文献检索

• 作者: 河島睦;他;伊藤耕他4名;Toshirou Kondoh
• 通讯作者: Toshirou Kondoh

IL-1β刺激滑膜細胞へのCOX阻害薬添加の影響

添加 COX 抑制剂对 IL-1β 刺激的滑膜细胞的影响

• 发表时间: 2012
• 作者: Ogura N;Takahashi K;Iwai S;Fujimoto Y;Hashimoto H;Kondoh T.;河島 睦;河島睦,小倉直美,阿久津美和,伊藤耕,近藤壽郎;Toshirou Kondoh.;河島睦他4名;河島睦他4名;河島 睦;河島 睦
• 通讯作者: 河島 睦