A marine lethal toxin polycavernoside A: synthesis and exploration of the molecular mechanism of action

从食用藻类Gracilaria edulis中分离出的一种海洋致死毒素(-)-聚海绵苷A已通过收敛方法实现了全合成。重点是两个关键片段的催化不对称合成以及它们通过Suzuki-Miyaura偶联和Keck大内酯化而结合。利用解除武装的概念，开发了L岩藻糖基D-木糖部分的高效合成方法。

A total synthesis of (-)-polycavernoside A, a marine lethal toxin isolated from the edible alga Gracilaria edulis, has been achieved via a convergent approach. The synthesis is highlighted by catalytic asymmetric syntheses of the two key fragments and their union through Suzuki-Miyaura coupling and Keck macrolactonization. Efficient synthesis of L-fucosyl-D-xylose part was developed by using armed-disarmed concept.