A marine lethal toxin polycavernoside A: synthesis and exploration of the molecular mechanism of action

聚海绵体苷A是一种海洋致命毒素，从可食用的紫菜中分离出来，通过聚合方法实现了(-)-多海绵体苷A的全合成。催化不对称合成了两个关键片段，并通过Suzuki-Miyaura偶联和Keck大内酯化将它们结合。采用“武装-解除武装”的概念，开发了L-焦酰基-d -木糖组分的高效合成方法。

A total synthesis of (-)-polycavernoside A, a marine lethal toxin isolated from the edible alga Gracilaria edulis, has been achieved via a convergent approach. The synthesis is highlighted by catalytic asymmetric syntheses of the two key fragments and their union through Suzuki-Miyaura coupling and Keck macrolactonization. Efficient synthesis of L-fucosyl-D-xylose part was developed by using armed-disarmed concept.