Studies on microbial secondary metabolism for development of biosynthetic technology tools
Studies on microbial secondary metabolism for development of biosynthetic technology tools
批准号:
22603011
负责人:
HAYAKAWA Yoichi
金额:
$3.0万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
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英文摘要
The genome analysis of a thioviridamide-producing organism revealed a gene encoding the thioviridamide precursor peptide (tvaA). Heterologous production of thioviridamide by 15 genes (tvaA- tvaO) identified the thioviridamide biosynthetic gene cluster including thioamide-forming genes. In the hatomarubigin biosynthetic gene cluster, hrbYand hrbUwere identified as a methylene-bridge forming gene and a methyltransferase gene, respectively. The hrbF-deficient gene cluster produced 5-hydroxyhatomarubigin E, suggesting that hrbFcontrols the hydroxylation regioselectivity.
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Biverlactones A-D, new circumventors of arbekacin resistance in MRSA
Biverlactones A-D,MRSA 中阿贝卡星耐药性的新规避者
DOI:
--
发表时间:
2011
期刊:
Penicillium sp
影响因子:
--
作者:
[Masato Iwatsuki, Toshiya Ishimori, Tsuyoshi Yamamoto, Keiko Takata, Mihoko Mori, Kenichi Nonaka, Rokuro Masuma, Yoichi Hayakawa, Hideaki Hanaki, Kazuro Shiomi, Satoshi Omura]
通讯作者:
Satoshi Omura
異種発現系を用いたhatomarubigin類の生産
使用异源表达系统生产 hamarubigins
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[伊澤真澄, 前田鮎美, 木股祥子, 川崎崇, 早川洋一]
通讯作者:
早川洋一
含チオアミド抗生物質thioviridamideの生合成研究
含硫代酰胺的抗生素硫代病毒酰胺的生物合成研究
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[渡邉安希子, 伊澤真澄, 川崎崇, 早川洋一]
通讯作者:
早川洋一
Hatomarubiginの生合成に関する研究
鸠丸红素的生物合成研究
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[川崎崇, 平島麗子, 山田佑樹, 武田真歩, 丸田智加, 前田鮎美, 佐藤はるか, 中井恵美, 早川洋一]
通讯作者:
早川洋一
a biosynthetic intermediate of hatomarubigins C and a substrate of HrbU O-methyltransferase
hamarubigins C 的生物合成中间体和 HrbU O-甲基转移酶的底物
DOI:
--
发表时间:
2010
期刊:
J. Antibiot.
影响因子:
--
作者:
[Takashi Kawasaki, Yuki Yamada, Tomoka Maruta, Ayumi Maeda, Yoichi Hayakawa: Hatomarubigin E]
通讯作者:
Yoichi Hayakawa: Hatomarubigin E
共 12 条
Development of biosynthetic technology tools by using microbial secondary metabolism
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批准号:25560407
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项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.5万
-
财政年份:2013
-
负责人:HAYAKAWA Yoichi
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依托单位:
The mechanism by which parasitoid wasp Asobara japaonoca
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批准号:24658053
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.66万
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财政年份:2012
-
负责人:HAYAKAWA Yoichi
-
依托单位:
Insect growth-blocking peptide (GBP) signaling pathway mediates acute immune reactions during infectious and non-infectious stress
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批准号:23370034
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$6.82万
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财政年份:2011
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负责人:HAYAKAWA Yoichi
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依托单位:
Analysis of GBP receptor structure and GBP signal transduction in hemocytes
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批准号:18370031
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.56万
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财政年份:2006
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负责人:HAYAKAWA Yoichi
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依托单位:
Demonstration of multiforms of insect cytokine receptors
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批准号:14340261
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$10.62万
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财政年份:2002
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负责人:HAYAKAWA Yoichi
-
依托单位:
Cytokine found in insects for the forsttime ; studies on its activation mechanism and multi function
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批准号:11640674
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
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财政年份:1999
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负责人:HAYAKAWA Yoichi
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依托单位:
Studies on free radical scavengers of microbial origin
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批准号:02660129
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.34万
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财政年份:1990
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负责人:HAYAKAWA Yoichi
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依托单位:
海外基金