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Studies on free radical scavengers of microbial origin

Studies on free radical scavengers of microbial origin
微生物来源的自由基清除剂的研究
批准号：
02660129
负责人：
HAYAKAWA Yoichi
金额：
$1.34万
依托单位：
The University of Tokyo
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1990
资助国家：
日本
项目状态：
已结题
起止时间：
1990 至 1991
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02660129/
关键词：
Free radicalsLipid peroxidationStreptomycesBenthocyaninPhenazinebenthocyanin

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中文摘要
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英文摘要
Oxygen-derived free radicals have been known to play a role in a variety of diseases such as inflammation, atherosclerosis, cerebral ischemia and cardiovascular diseases. In the course of a screening for free radical scavengers of microbial origin, an actinomycete identified as Streptomyces prunicolor was found to produce three new active substances, designated benthocyanins A, B and C. The structures of the benthocyanins were elucidated to consist of a modified phenazine chromophore with a phenyl group and a geranyl side chain based on NNM and mass spectral analysis.Benthocyanins A, B and C inhibited lipid peroxidation in rat liver microsomes at the IC_<50>s of 0.29, 0.16 and 0.26 mug/ml, respectively. The benthocyanins also inhibited hemolysis of rat erythrocytes by a radical producer, AAPH. The IC_<50>s were 0.42 mug/ml for benthocyanin A, 0.92 mug/ml for B and 0.64 mug/ml for C.
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Kazuo Shin-ya: "Benthocyanins B and C,new free radical scavengers from Streptomyces prunicolor." Journal of Organic Chemistry.
Kazuo Shin-ya：“Benthocyanins B 和 C，来自 Streptomyces prunicolor 的新型自由基清除剂。”
DOI： --
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作者： []
通讯作者：
Kazuo Shin-ya: "The structure of benthocyanin A,a new free radical scavenger of microbial origin" Tetrahedron Letters. 32. 943-946 (1991)
Kazuo Shin-ya：“微生物来源的新型自由基清除剂底色青素 A 的结构”四面体快报。
DOI： --
发表时间：
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作者： []
通讯作者：
Kazuo Shin-ya: "The structure of benthocyanin A, a new free radical scavenger of microbial origin." Tetrahedron Letters. 32. 943-946 (1991)
Kazuo Shin-ya：“微生物来源的新型自由基清除剂 Benthocyanin A 的结构。”
DOI： --
发表时间：
期刊：
影响因子： --
作者： []
通讯作者：
Kazuo Shin-ya: "Benthocyanins B and C, new free radical scavengers from Streptomyces prunicolor." Journal of Organic Chemistry.
Kazuo Shin-ya：“Benthocyanins B 和 C，来自 Streptomyces prunicolor 的新型自由基清除剂。”
DOI： --
发表时间：
期刊：
影响因子： --
作者： []
通讯作者：
共 7 条
    Development of biosynthetic technology tools by using microbial secondary metabolism
    • 批准号：
      25560407
    • 项目类别：
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额：
      $2.5万
    • 财政年份：
      2013
    • 负责人：
      HAYAKAWA Yoichi
    • 依托单位：
      Tokyo University of Science
    The mechanism by which parasitoid wasp Asobara japaonoca
    • 批准号：
      24658053
    • 项目类别：
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额：
      $2.66万
    • 财政年份：
      2012
    • 负责人：
      HAYAKAWA Yoichi
    • 依托单位：
      Saga University
    Insect growth-blocking peptide (GBP) signaling pathway mediates acute immune reactions during infectious and non-infectious stress
    • 批准号：
      23370034
    • 项目类别：
      Grant-in-Aid for Scientific Research (B)
    • 资助金额：
      $6.82万
    • 财政年份：
      2011
    • 负责人：
      HAYAKAWA Yoichi
    • 依托单位：
      Saga University
    Studies on microbial secondary metabolism for development of biosynthetic technology tools
    • 批准号：
      22603011
    • 项目类别：
      Grant-in-Aid for Scientific Research (C)
    • 资助金额：
      $3.0万
    • 财政年份：
      2010
    • 负责人：
      HAYAKAWA Yoichi
    • 依托单位：
      Tokyo University of Science
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