A study of novel lighting system based on the frequency characteristics of non-visual photoreceptors.

基于非视觉感光器频率特性的新型照明系统的研究。

• 批准号: 22657064
• 负责人: MORITA Takeshi
• 金额: $ 2.24万
• 依托单位: Fukuoka Women's University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22657064/
• 关键词: テクノ・アダプタビリティー; 生体リズム; 環境; 生理学; 光

The frequency characteristics of non-visual photoreceptor; melanopsin expressing retinal ganglion cells (mRGCs) were investigated with the light which stimulates mRGCs independently. The results showed the mRGCs response to a light stimulus at around 8Hz was high. In contrast, th e response to light stimulus tended to be smaller under light condition that change at lower and higher frequencies. The effects of blue LED light on melatonin secretion were investigated under the v arious frequencies. The melatonin secretion was not inhibited by the blue LED light with frequency changes at 1000Hz and 7.14Hz, although it was inhibited by the constant blue LED light at nighttime.

研究了表达黑视素的非视觉光感受器视网膜神经节细胞（mRGCs）在光刺激下的频率特性。结果表明，mRGCs对8Hz左右的光刺激的反应较高。相反，在低频和高频变化的光刺激条件下，对光刺激的反应往往较小。研究了不同频率下蓝光LED对小鼠褪黑素分泌的影响。1000Hz和7.14Hz频率变化的蓝光LED灯对褪黑素分泌无抑制作用，而夜间恒定的蓝光LED灯对褪黑素分泌有抑制作用。

项目成果

ERG responses of melanopsin-expressing retinal ganglion cells in the human retina

人视网膜中表达黑视蛋白的视网膜神经节细胞的 ERG 反应

• 发表时间: 2011
• 作者: Y.Fukuda;S.Tsujimura;S.Higuchi;A.Yasukouchi;T.Morita
• 通讯作者: T.Morita

多原色光源装置を用いたメラノプシンを含む網膜神経節細胞の挙動把握

使用多基色光源装置了解含有黑视蛋白的视网膜神经节细胞的行为

• 发表时间: 2010
• 作者: 福田裕美;辻村誠一;樋口重和;安河内朗;森田健
• 通讯作者: 森田健

メラノプシン網膜神経節細胞と錐体の網膜電図における光応答性の違い

黑视蛋白视网膜神经节细胞和视锥细胞视网膜电图中光响应性的差异

• 发表时间: 2011
• 作者: 福田裕美;辻村誠一;樋口重和;安河内朗;森田健
• 通讯作者: 森田健

The response of melanopsin-expressing retinal ganglion cells to light stimuli with frequency changes

表达黑视蛋白的视网膜神经节细胞对光刺激的响应随频率的变化

• 发表时间: 2010
• 作者: Y. Fukuda;S. Tsujimura;S. Higuchi;A. Yasukouchi;T. Morita
• 通讯作者: T. Morita

Diurnal variation in responses of melanopsin expressing retinal ganglion cells in the human retina

人视网膜中表达黑视蛋白的视网膜神经节细胞反应的昼夜变化

• 发表时间: 2011
• 作者: Y.Fukuda;S.Tsujimura;S.Higuchi;A.Yasukouchi;T.Morita
• 通讯作者: T.Morita