Search for anti-malaria agents from marine organisms

从海洋生物中寻找抗疟疾药物

• 批准号: 22658065
• 负责人: MATSUNAGA Shigeki
• 金额: $ 2.25万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22658065/
• 关键词: 天然物化学; 海洋生物; テルペン生合成; 抗菌活性; 遺伝子操作; 枯草菌; マラリア; テルペン; 生合成; 組換え微生物; 生物活性

We searched for compounds selectively toxic against malaria parasites from marine organisms. The bioassay was examined to see differential antimicrobial activity against bacteria dependent on mavalonate pathway and non-mevalonate pathway. We screened the 736 extracts of marine invertebrates collected along the coast of Japan. Active compounds from hit organisms were isolated and their structures were elucidated. We characterized several compounds from an unidentified marine sponge from Kagoshima and a soft coral from Tanegashima. The selectivities of the isolated compounds were not noteworthy.

我们从海洋生物中寻找对疟疾寄生虫有选择性毒性的化合物。生物测定法考察了对依赖于甲羟戊酸途径和非甲羟戊酸途径的细菌的不同抑菌活性。我们筛选了日本沿海收集的736种海洋无脊椎动物提取物。从hit生物中分离得到活性化合物，并对其结构进行了分析。我们从鹿儿岛的一种未识别的海绵和种子岛的软珊瑚中鉴定了几种化合物。分离得到的化合物的选择性不显著。