Search for anti-malaria agents from marine organisms
Search for anti-malaria agents from marine organisms
批准号:
22658065
负责人:
MATSUNAGA Shigeki
金额:
$2.25万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2011
中文摘要
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英文摘要
We searched for compounds selectively toxic against malaria parasites from marine organisms. The bioassay was examined to see differential antimicrobial activity against bacteria dependent on mavalonate pathway and non-mevalonate pathway. We screened the 736 extracts of marine invertebrates collected along the coast of Japan. Active compounds from hit organisms were isolated and their structures were elucidated. We characterized several compounds from an unidentified marine sponge from Kagoshima and a soft coral from Tanegashima. The selectivities of the isolated compounds were not noteworthy.
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国内基金
海外基金
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