Search for anti-malaria agents from marine organisms

我们从海洋生物中寻找对疟疾寄生虫有选择性毒性的化合物。检查生物测定以观察对依赖于甲羟戊酸途径和非甲羟戊酸途径的细菌的差异抗微生物活性。我们筛选了沿着日本海岸收集的736种海洋无脊椎动物提取物。从受攻击的生物体中分离出活性化合物，并鉴定了其结构。我们从鹿儿岛的一种不明海绵和种子岛的一种软珊瑚中提取了几种化合物。分离的化合物的选择性不值得注意。

We searched for compounds selectively toxic against malaria parasites from marine organisms. The bioassay was examined to see differential antimicrobial activity against bacteria dependent on mavalonate pathway and non-mevalonate pathway. We screened the 736 extracts of marine invertebrates collected along the coast of Japan. Active compounds from hit organisms were isolated and their structures were elucidated. We characterized several compounds from an unidentified marine sponge from Kagoshima and a soft coral from Tanegashima. The selectivities of the isolated compounds were not noteworthy.