Development and application of nanotubes based on polytheonamides

在对聚酰胺的进一步结构研究中，合成了44^< >残基氨基酸的候选结构。结果表明，相关产物的结构为β，β-二甲基蛋氨酸。聚乙胺B的氧化还原反应证实了这一点。与此同时，聚酰胺A的结构被确定为非对映体，其硫原子的构型与44^< >残基不同。44^<th>残基的绝对立体化学是通过提供c端内酯的聚酰胺的BrCN反应来确定的，然后在手性固定相上进行GC分析。考察了聚酰胺的通道形成活性。聚茶酰胺A和B与细菌线状肽gramicidin A一样，均被纳入脂质双分子层并传导一价阳离子，聚茶酰胺形成的通道呈现开闭状态。这一特征的形成机制有待进一步研究。

In further structural study of polytheonamides, the candidates of the structures for the 44^<th> residue amino acid were synthesized. As the result, the structure of the pertinent resudue was concluded to be β,β-dimethylmethionine. This was confirmed by chemical reaction of polytheonamide B by oxidation and reduction. In the meantime, the structure of polytheonamide A was firmly established as a diastereomer differing in the configuration of the sulfur atom in the 44^<th> residue. The absolute stereochemistry of the 44^<th> residue was determined by BrCN reaction of polytheonamides affording the C-terminal lactone, and the following GC analysis on a chiral stationary phase.Channel forming activity of polytheonamides were examined. Both polytheonamides A and B are incorporated into the lipid bilayer and conducted monovalent cations as does bacterial linear peptide gramicidin A. The channel formed by polytheonamides showed open and close state. The mechanism of this character needs further study.