Studies on the Transition Metal-Rare Earth Metal/Dinuclear Schiff Base Catalysts, Mechanistic Studies and Application to New Asymmetric Reactions

过渡金属-稀土金属/双核希夫碱催化剂研究、机理研究及其在新型不对称反应中的应用

• 批准号: 20685008
• 负责人: MATSUNAGA Shigeki
• 金额: $ 16.39万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (A)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20685008/
• 关键词: 触媒; 不斉合成; 不斉触媒; サレン; 非天然アミノ酸; 医薬品合成; 希土類触媒; シッフ塩基; 複核錯体

Characterization of hetero-dinuclear rare earth metal/transition metal Schiff base complexes, as well as their applications to various enantioselective reactions have been investigated. Catalytic asymmetric nitro-Mannich-type reactions, catalytic asymmetric α-addition of isocyanato esters to aldehydes, and so on have been successfully developed, leading to providing useful synthetic methods for chiral nitrogen-containing building blocks. Thus, the achievement can contribute for the efficient synthesis of pharmaceuticals.

本文研究了异双核稀土金属/过渡金属Schiff碱配合物的表征及其在各种不对称反应中的应用。催化不对称硝基Mannich反应、异氰酸酯对醛的催化不对称α-加成反应等，为手性含氮结构单元的合成提供了新的方法。因此，该成果可以有助于药物的有效合成。

项目成果

Bimetallic Cooperative Asymmetric Catalysis for C-C Bond Formation; Green Chemistry For Catalytic C-C Bond Formation

C-C键形成的双金属协同不对称催化；

• 发表时间: 2008
• 作者: Dimkley D.J.;Hiroi;Y.;Satish-Kumar;M.;S. Matsunaga
• 通讯作者: S. Matsunaga

Construction of Contiguous Tetrasubstituted Chiral Carbon Stereocenters via Direct Catalytic Asymmetric Aldol Reaction of α-Isothiocyanato Esters to Ketones

通过α-异硫氰酸酯直接催化不对称羟醛反应构建连续四取代手性碳立构中心

• 发表时间: 2009
• 期刊: J.Am.Chem.Soc. 131
• 作者: T.Yoshino;H.Morimoto;G.Lu;S.Matsunaga;M.Shibasaki
• 通讯作者: M.Shibasaki

Direct Catalytic Asymmetric Mannich-type Reaction of R-Keto Phosphonate Using a Dinuclear Ni_2-Schiff Base Complex

双核Ni_2-席夫碱配合物直接催化R-酮基膦酸不对称曼尼希型反应

• 发表时间: 2008
• 期刊: Org. Lett 10
• 作者: Z. Chen;K. Yakura;S. Matsunaga;M. Shibasaki
• 通讯作者: M. Shibasaki

Catalytic Asymmetric Synthesis of 3-Aminooxindoles: Enantiofacial Selectivity Switch in Bimetallic vs Monometallic Schiff Base Catalysis

• DOI: 10.1021/ja908906n
• 发表时间: 2010-02-03
• 期刊: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
• 影响因子: 15
• 作者: Mouri, Shinsuke;Chen, Zhihua;Shibasaki, Masakatsu
• 通讯作者: Shibasaki, Masakatsu

Development of multimetallic asymmetric catalysisthrough chiral ligand design

通过手性配体设计开发多金属不对称催化

• 发表时间: 2009
• 作者: Satish-Kumar;M.;Hermann;J.;Miyamoto;T.;Osanai;Y.;Motoyoshi;Y.;S. Matsunaga
• 通讯作者: S. Matsunaga