Discovery of Highly Selective Antifungal Agents from Marine Invertebrates

从日本海洋无脊椎动物中分离出以下新化合物，作为生物测定指导的分离监测抗真菌活性的结果。从Mycale sp.中分离到新的Mycalolid在Gokasho海湾采集到的三个新的真菌内酯已被分离出来作为抗真菌成分。根据波谱数据，将它们分别鉴定为30-羟基麦冬内酯A、32-羟基麦冬内酯A和38-羟基麦冬内酯B。从刺五加(Acanthodendrilla sp.)在Gokasho海湾采集到的10个高度羟基的甾醇硫酸盐已被分离出来。通过对光谱数据的解析，确定了它们的结构。红景天苷和橙皮苷11个化合物，分别含有一个四酸和一个共轭多烯发色团，称为红景天苷和橙皮苷，它们是从采自八条岛的水母中分离得到的。根据光谱数据和化学降解确定了它们的结构。

From Japanese marine invertebrates, following novel compounds have been isolates as a result of bioassay-guided fractionation monitoring antifungal activity.1. New mycalolidesFrom Mycale sp. collected in the Gulf of Gokasho, three novel mycalolides have been isolated as antifungal constituents. They were assigned as 30-hydroxymycalolide A, 32-hydromycalolide A, and 38-hydroxymycaloude B on the basis of spectral data.2. Acanthosterol sulfatesFrom Acanthodendrilla sp. collected in the Gulf of Gokasho 10 highly hydroxylated sterol sulfates have been isolated. Their structures were determined by interpretation of spectral data.3. Rubrosides and aurantosidesEleven compounds that have a tetramic acid and a conjugated polyene chromophore, termed rubrosides and aurantosides, have been isolated from the Siliquariaspongeia japnica collected off Hachijo Island. Their structures were assigned on the basis of spectral data and chemical degradation.