Discovery of Highly Selective Antifungal Agents from Marine Invertebrates

从海洋无脊椎动物中发现高选择性抗真菌剂

• 批准号: 10460091
• 负责人: MATSUNAGA Shigeki
• 金额: $ 9.73万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10460091/
• 关键词: sponge; antifungal; marine; invertebrates; isolation; structure; elucidation

From Japanese marine invertebrates, following novel compounds have been isolates as a result of bioassay-guided fractionation monitoring antifungal activity.1. New mycalolidesFrom Mycale sp. collected in the Gulf of Gokasho, three novel mycalolides have been isolated as antifungal constituents. They were assigned as 30-hydroxymycalolide A, 32-hydromycalolide A, and 38-hydroxymycaloude B on the basis of spectral data.2. Acanthosterol sulfatesFrom Acanthodendrilla sp. collected in the Gulf of Gokasho 10 highly hydroxylated sterol sulfates have been isolated. Their structures were determined by interpretation of spectral data.3. Rubrosides and aurantosidesEleven compounds that have a tetramic acid and a conjugated polyene chromophore, termed rubrosides and aurantosides, have been isolated from the Siliquariaspongeia japnica collected off Hachijo Island. Their structures were assigned on the basis of spectral data and chemical degradation.

从日本海洋无脊椎动物中分离出以下新化合物，作为生物测定引导分离监测抗真菌活性的结果。从Gokasho湾的Mycale sp.中分离出3个新的mycalolides作为抗真菌成分。根据光谱数据分别鉴定为30-hydroxymycalolide A、32-hydromycalolide A和38- hydroxymycalolide B。从Gokasho海湾收集的棘棘皮甾醇sp.中分离出10种高度羟基化的硫酸甾醇。它们的结构是通过光谱数据的解释来确定的。芦花苷和金糖苷从八条岛采集的枇杷叶中分离到11种具有四羧酸和共轭多烯发色团的化合物，称为芦花苷和金糖苷。根据光谱数据和化学降解对其结构进行了划分。

项目成果

S. Matsunaga ら: "Relative and Absolute Stereochemistry of Mycalolides, Bioactive Macrolides from the Marine Sponge Mycale magelanica"J. Am. Chem. Soc.. 121. 5605-5606 (1999)

S. Matsunaga 等人：“来自海洋海绵 Mycale magelanica 的生物活性大环内酯的相对和绝对立体化学”J. Am. 121. 5605-5606 (1999)

N. Sata ら: "Aurantosides D, E, and F: New Antifungal Tetramic Acid Glycosides from the Marine Sponge Siliqualia spongia japonica"J. Nat. Prod.. 62. 969-971 (1999)

N. Sata 等人：“Aurantosides D、E 和 F：来自海洋海绵 Siliqualia spongia japonica 的新型抗真菌四酸苷”J. Nat. 62. 969-971 (1999)

Shigeki Matsunaga ら: "New Mycalolides from the Marine Sponge Mycale sp and Their Interconversion" Journal of Natural Products. 61. 1164-1167 (1998)

Shigeki Matsunaga 等人：“来自海洋海绵 Mycale sp 的新 Mycaloliides 及其相互转化”《天然产物杂志》61. 1164-1167 (1998)。

N. Sata ら: "Rubrosides A-H, New Bioactive Tetramic Acid Glycosides from the Marine Sponge Siliqualia spongia japonica"J. Org. Chem.. 64. 2331-2339 (1999)

N. Sata 等人：“Rubrosides A-H，来自海洋海绵 Siliqualia spongia japonica 的新型生物活性四酸苷”J. Org. 64. 2331-2339 (1999)

S. Tsukamoto et al.: "Acanthosterol Sulfates A-J : New Antifungal steruidel Sulfates from a marine spurge Acanthodendrilla sp."J. Nat. Prod. 61. 1374-1378 (1998)

S. Tsukamoto 等人：“硫酸棘甾醇 A-J：来自海洋大戟 Acanthodendrilla sp 的新型抗真菌 steruidel 硫酸盐”J。