Does cytokine directly reacted with bacteria?

细胞因子直接与细菌反应吗？

• 批准号: 22659333
• 负责人: KOMATSUZAWA Hitoshi
• 金额: $ 2.04万
• 依托单位: Kagoshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22659333/
• 关键词: 細菌; 歯学; サイトカイン; 細菌感染; ケモカイン; 黄色ブドウ球菌; 口腔レンサ球菌; 歯肉上皮細胞; 免疫抑制; 炎症; サイトイン; 抗菌性ペプチド; 抗菌力; 口腔内細菌; 上皮細胞

The purpose of this research is to demonstrate the new function of cytokines. We investigated the antibacterial activity of cytokines, the cytokine affinity to bacterial cells and the effect of cytokine treatment on bacterial attachment to mammal cells. We found that MIP3alpha and IL8, positive charged peptides, were able to bind bacterial cells, and had weak antibacterial effect, while biding of cytokines to bacterial cells had no effect on the bacterial attachment to mammal cells. In conclusion, it is suggested that some cytokines binds to bacteria causing to modulate the immune responses

本研究的目的是为了证明细胞因子的新功能。我们研究了细胞因子的抑菌活性、细胞因子对细菌细胞的亲和力以及细胞因子处理对细菌附着于哺乳动物细胞的影响。我们发现，带正电荷的多肽MIP3alpha和IL8能够结合细菌细胞，抗菌作用较弱，而细胞因子对细菌细胞的粘附作用对细菌对哺乳动物细胞的附着没有影响。综上所述，一些细胞因子与细菌结合，调节免疫反应

项目成果

Additive effects of orexin B and vasoactive intestinal polypeptide on LL-37-mediated antimicrobial activities.

• DOI: 10.1016/j.jneuroim.2010.11.009
• 发表时间: 2011-04
• 期刊: JOURNAL OF NEUROIMMUNOLOGY
• 影响因子: 3.3
• 作者: Ohta, Kouji;Kajiya, Mikihiko;Zhu, Tongbo;Nishi, Hiromi;Mawardi, Hani;Shin, Jane;Elbadawi, Leena;Kamata, Nobuyuki;Komatsuzawa, Hitoshi;Kawai, Toshihisa
• 通讯作者: Kawai, Toshihisa

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