Selection of osteogenic progenitor cells in gingival tissue

牙龈组织中成骨祖细胞的选择

• 批准号: 22659359
• 负责人: NISHIMURA Masahiro
• 金额: $ 2.04万
• 依托单位: Nagasaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22659359/
• 关键词: 歯肉幹細胞; 骨再生; 歯槽骨再生

The purpose of this project was to discover the method to collect osteogenic cells in gingival tissues. Phenotype of human gingival cells was heterogenic, and we could not uniformly divide them by MACS. Among tested antibodies, anti-CD166 induced one of gingival cells and mesenchymal stem cells as well. Anti-CD166 might bind to the receptor of the cells which have the ability for osteogenic differentiation. MACS might show additive role for selection of these osteogenic progenitor cells.

本课题旨在探索牙龈组织中成骨细胞的采集方法。人牙龈细胞的表型是异质的，我们不能均匀地划分它们的MACS。在测试的抗体中，抗CD166诱导牙龈细胞和间充质干细胞之一，以及。抗CD166抗体可能与具有成骨分化能力的细胞的受体结合。MACS可能对这些成骨祖细胞的选择具有附加作用。