Development of polymer materials for ultralow invasive periosteum lifting

超低侵入骨膜提升高分子材料的开发

• 批准号: 24659878
• 负责人: NISHIMURA Masahiro
• 金额: $ 2.41万
• 依托单位: Kagoshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24659878/
• 关键词: 骨造成; 骨増生; 骨膜挙上; 骨膜; 再生医学

Alveolar ridge tends to absorb by periodontal diseases or aging, and its augmentation technique is required in many cases before dental implantation. However alveolar ridge augmentation is not an easy surgery. The purpose of this study was to evaluate the best material or method to reserve a required space for periosteum augmentation. We used PLLA/PLGA membrane as the periosteum lifting auto-swelling material on rat calvaria model. As a temporary insertion usage, the membrane should be removed within 3 weeks before its self resorption. Interestingly, ectopic bone formations in the PLLA/PLGA membrane were observed after 9 week. Insertion of PLLA/PLGA membrane underneath the periosteum might be an alternative method for alveolar ridge augmentation.

牙槽嵴容易因牙周疾病或老化而吸收，在许多情况下，牙种植前需要进行牙槽嵴增强技术。然而，牙槽嵴增高不是一个容易的手术。本研究的目的是评价最佳的材料或方法，以保留所需的空间，骨膜增加。采用PLLA/PLGA膜作为骨膜提升自膨材料制作大鼠颅骨模型。作为临时插入使用，膜应在其自身吸收前3周内取出。有趣的是，在9周后观察到PLLA/PLGA膜中的异位骨形成。在骨膜下植入PLLA/PLGA膜可能是牙槽嵴增高的一种替代方法。