New diagnostic technique for malignant melanoma by blood flow velocity imaging

血流速度成像诊断恶性黑色素瘤的新技术

• 批准号: 22700521
• 负责人: ISHIDA Hiroki
• 金额: $ 2.5万
• 依托单位: National Institute of Technology, Toyama College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22700521/
• 关键词: 画像診断システム; 腫瘍診断; 新生血管; 血流速

We have developed a micro multipoint laser Doppler velocimeter(μ-MLDV) for in-vivo visualization of melanoma tumor based on flow velocities. Malignant transformation results in a sudden rapid increase in growth along with the formation of new blood vessels to supply oxygen, nutrients, and metabolites to cancer cells. The blood flow velocity in a lesion more than doubled 9 days after transplantation. After 12 days, we observed the formation of new blood vessels in the tumor. Theμ-MLDV is potentially a useful diagnostic technique for distinguishing benign and malignant tumors.

我们研制了一种微型多点激光多普勒测速仪（μ-MLDV），用于基于流速的黑色素瘤体内可视化。恶性转化导致生长沿着新血管的形成以向癌细胞供应氧气、营养物和代谢物的突然快速增加。移植后9天，病变中的血流速度增加了一倍以上。12天后，我们观察到肿瘤中新血管的形成。μ-MLDV是鉴别良恶性肿瘤的一种潜在的诊断技术。

项目成果

Noninvasive In-vivo Measurements of Microvessels by Reflection-type Micro Multipoint Laser Doppler Velocimeter

反射式微型多点激光多普勒测速仪对微血管的无创体内测量

• DOI: 10.1143/jjap.51.032701
• 发表时间: 2012
• 期刊: Japanese Journal of Applied Physics
• 影响因子: 1.5
• 作者: H. Ishida;T. Andoh;S. Akiguchi;T. Hachiga;M. Ishizuka;T. Shimizu;H. Shirakawa;and Y. Kuraishi
• 通讯作者: and Y. Kuraishi

Reflection-type micro multipoint LDV for measuring velocity distributions in blood vessels

用于测量血管速度分布的反射式微型多点 LDV

• DOI: 10.1063/1.3609864
• 发表时间: 2011
• 期刊: Review of Scientific Instruments
• 影响因子: 1.6
• 作者: H. Ishida;D. Kobayashi;H. Shirakawa;T. Andoh;S. Akiguchi;T. Wakisaka;M. Ishizuka;and T. Hachiga
• 通讯作者: and T. Hachiga

Blood flow velocity imaging of malignant melanoma by micro multipoint laser Doppler velocimetry

• DOI: 10.1063/1.3486678
• 发表时间: 2010-09
• 期刊: Applied Physics Letters
• 影响因子: 4
• 作者: H. Ishida;T. Andoh;S. Akiguchi;H. Shirakawa;D. Kobayashi;Y. Kuraishi;T. Hachiga