New diagnostic technique for malignant melanoma by blood flow velocity imaging

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We have developed a micro multipoint laser Doppler velocimeter(μ-MLDV) for in-vivo visualization of melanoma tumor based on flow velocities. Malignant transformation results in a sudden rapid increase in growth along with the formation of new blood vessels to supply oxygen, nutrients, and metabolites to cancer cells. The blood flow velocity in a lesion more than doubled 9 days after transplantation. After 12 days, we observed the formation of new blood vessels in the tumor. Theμ-MLDV is potentially a useful diagnostic technique for distinguishing benign and malignant tumors.