Development of caged compounds via photoinduced electron transfer reaction

合成了通过光照射控制活细胞各种功能的笼状化合物，并研究了它们的光化学裂解反应。光吸收部分使用了各种颜料和芳香族体系，这些部分和接受电子的部分与亚甲基链相连。此外，在接受吡啶的电子部分引入了生物活性谷氨酸或醋酸基。结果表明，乙酸的释放是通过电子转移反应从芳香族染料转移到吡啶部分，然后在光照射下发生裂解反应进行的。在这种情况下，在牺牲给体的存在下，该反应的量子产率达到了很高的值。

Caged compounds which control various functions of living cells by light irradiation have been synthesized and their photochemical cleavage reactions have been studied. Various kinds of pigments and aromatic systems were used for the light absorption part, and these parts and the electron accepting part were connected with the methylene chain. Furthermore, bioactive glutamic acid or acetic acid group was introduced at the electron accepting pyridinium moiety. As a result, release of acetic acid took place via electron transfer reaction from the aromatic dyes to the pyridinium part followed by cleavage reaction with light irradiation. In this case the quantum yield for this reaction attained very high value in the presence of sacrificial donors.