Genetic analyses of the molecular and neuronal mechanisms for the regulation of forgetting
遗忘调节的分子和神经机制的遗传分析
基本信息
- 批准号:23370002
- 负责人:
- 金额:$ 11.48万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (B)
- 财政年份:2011
- 资助国家:日本
- 起止时间:2011-04-01 至 2014-03-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Animals show a variety of behavioral plasticity, in which animals change their behavior dependent on their environments. Those behavioral plasticity must be sustained for an appropriate time to survive. However, the neuronal and molecular mechanisms of forgetting of memories are poorly understood. Therefore, we studied on the forgetting of olfactory adaptation in C. elegans as a model for the behavioral plasticity. We found that the forgetting of the olfactory adaptation is actively regulated by the environmental conditions before and after conditioning. In addition, we identified a pair of neurons that secrete signals for the forgetting of the olfactory adaption in other sensory neurons. These results suggested that the forgetting is actively regulated by the neuronal communications.
动物表现出多种行为可塑性,其中动物会改变其行为取决于其环境。这些行为可塑性必须在适当的时间内维持生存。但是,忘记记忆的神经元和分子机制知之甚少。因此,我们研究了秀丽隐杆线虫中忽略嗅觉适应性,作为行为可塑性的模型。我们发现,遗忘嗅觉适应受到调节前后环境条件的积极调节。此外,我们确定了一对神经元,该神经元分泌信号,以忘记其他感觉神经元中的嗅觉适应性。这些结果表明,遗忘是由神经元通信积极调节的。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
C.elegans神経ネットワークの4次元Ca2+イメージング
线虫神经网络的 4 维 Ca2+ 成像
- DOI:
- 发表时间:2011
- 期刊:
- 影响因子:0
- 作者:H Kurokawa;著者129名中65番目;中山潤一;Kunihiro Abe;寺本孝行
- 通讯作者:寺本孝行
Isolation of mutants for forgetting signals of olfactory adaptation.
分离遗忘嗅觉适应信号的突变体。
- DOI:
- 发表时间:2012
- 期刊:
- 影响因子:0
- 作者:Kitazono T.;Inoue A.;Ishihara T.
- 通讯作者:Ishihara T.
Molecular and neural mechanisms for behavioral choice between two conflicting alternatives in C. elegans
线虫两种相互冲突的选择之间行为选择的分子和神经机制
- DOI:
- 发表时间:2011
- 期刊:
- 影响因子:0
- 作者:黒川紘子;饗庭正寛,小野田雄介;Takeshi Ishihara
- 通讯作者:Takeshi Ishihara
記憶の忘却を制御するTIR-1/JNK-1経路の下流因子の探索
寻找控制记忆遗忘的TIR-1/JNK-1通路下游因子
- DOI:
- 发表时间:2013
- 期刊:
- 影响因子:0
- 作者:北園智弘;井上明俊;石原健
- 通讯作者:石原健
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ISHIHARA Takeshi其他文献
ISHIHARA Takeshi的其他文献
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{{ truncateString('ISHIHARA Takeshi', 18)}}的其他基金
Establishing a new method to analyze neuronal activities of all individual neurons of C. elegans CNS.
建立一种新方法来分析线虫中枢神经系统所有单个神经元的神经元活动。
- 批准号:
24650167 - 财政年份:2012
- 资助金额:
$ 11.48万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
Development of evaluation method of side wind risks and countermeasures for railway system and its verification by field tests
铁路系统侧风风险评估方法及对策开发及现场试验验证
- 批准号:
23360194 - 财政年份:2011
- 资助金额:
$ 11.48万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Dynamic response prediction of floating wind turbine considering the coupling of the floater and the wind turbine, and its verification by measurement
考虑浮体与风力机耦合的浮动式风力机动态响应预测及实测验证
- 批准号:
20360199 - 财政年份:2008
- 资助金额:
$ 11.48万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
A study of wind and seismic response analysis of wind turbine and its verification by a field test
风力发电机组风震响应分析及现场试验验证研究
- 批准号:
18360212 - 财政年份:2006
- 资助金额:
$ 11.48万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Mechanisms of neurodegeneration in an animal model of tauopathies
tau蛋白病动物模型中神经变性的机制
- 批准号:
18590942 - 财政年份:2006
- 资助金额:
$ 11.48万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Mechanisms of Sensory Processing in C.elegans Neuronal Circuits.
线虫神经元回路中的感觉处理机制。
- 批准号:
18370004 - 财政年份:2006
- 资助金额:
$ 11.48万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Development of wind climate information system for improvement of maintenance strategy of civil engineering structures and its verification by observations
改进土木工程结构维护策略的风气候信息系统开发及其观测验证
- 批准号:
16360223 - 财政年份:2004
- 资助金额:
$ 11.48万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Analyses of molecular mechanisms of sensory processing in C.elegans
线虫感觉加工的分子机制分析
- 批准号:
14580688 - 财政年份:2002
- 资助金额:
$ 11.48万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Development of a real time prediction system for local wind assessment based on regional atmospheric models and its verification by the field tests
基于区域大气模式的局地风速评估实时预报系统开发及现场试验验证
- 批准号:
14350239 - 财政年份:2002
- 资助金额:
$ 11.48万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Development of local wind prediction syste148 for improvement of wind resistant performance of the civil engineering structure in the mountainous region
提高山区土木工程结构抗风性能的局部风力预报系统开发148
- 批准号:
13555125 - 财政年份:2001
- 资助金额:
$ 11.48万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
相似海外基金
Mechanisms for forgetting in olfactory learning in C. elegans
线虫嗅觉学习的遗忘机制
- 批准号:
19H03326 - 财政年份:2019
- 资助金额:
$ 11.48万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Bidirectional regulation of synaptic transmission during C. elegans thermotaxis behavior
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17K07499 - 财政年份:2017
- 资助金额:
$ 11.48万 - 项目类别:
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了解行为可塑性背后的分子动力学
- 批准号:
16H06175 - 财政年份:2016
- 资助金额:
$ 11.48万 - 项目类别:
Grant-in-Aid for Young Scientists (A)
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线虫的记忆重建
- 批准号:
16KT0172 - 财政年份:2016
- 资助金额:
$ 11.48万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Study for establishing a method to optically and cell-specifically manipulate single locus gene expression
建立光学和细胞特异性操纵单基因座基因表达的方法的研究
- 批准号:
15K14575 - 财政年份:2015
- 资助金额:
$ 11.48万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research