Assessment of bone tissue as a central regulator for hematopoiesis

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Osteocytes are a major cell component in the bone tissue. We utilized DMP1-DTR Tg mouse model, in which diphteria toxin receptor (DTR) is specifically expressed in osteocytes and diphteria toxin injection induces the generation of osteocyte-less (OL) mouse, to reveal the the function of osteocytes for bone marrow niche and remote organs. We found that osteocytes send a supporting signal to osteoblastic niche and this pathway is controlled by the sympathetic nervous system. Furthermore, we showed that osteocytes regulate primary lymphoid organs such as thymus and fat metabolism. Our study proposes "the bone pinnacled functional orchestration of multiple organs".