Development of Innovative Targeting Artificial pulmonary surfactant preparations by Nanomedicine
Development of Innovative Targeting Artificial pulmonary surfactant preparations by Nanomedicine
批准号:
23510134
负责人:
SHIBATA Osamu
金额:
$3.49万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2013
中文摘要
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英文摘要
The model peptide in artificial pulmonary surfactant (PS) changes its secondary structure from alpha-helix to beta-sheet upon lateral compression. However, in the presence of anionic lipids such as phosphatidylglycerol and palmitic acid, the conversion of the structure is found to prevent from the spectroscopic aspect. And fluorinated compound additive in PS also very effective for PS preparation. The mechanism and function of PS across the interface have been elucidated from the thermodynamic, morphological, and spectroscopic perspectives.
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Surface property and miscibility of a partially fluorinated amphiphile (F4H11OH) with dipalmitoylphosphatidylcholine
部分氟化两亲物 (F4H11OH) 与二棕榈酰磷脂酰胆碱的表面性质和混溶性
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[H. Nakahara, A. Ohmine, O.Shibata]
通讯作者:
O.Shibata
Fluorocarbon-hybrid pulmonary surfactants towards the replacement therapy : A Langnluir monolayer study
碳氟杂化肺表面活性剂替代疗法:Langnluir 单层研究
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[上原 聖奈, 中原 広道, 藤田 一郎, 坂元 政一, 中村 承平, 柴田 攻, 中原広道, 中原広道, 中原広道]
通讯作者:
中原広道
長崎国際大学薬学部薬品物理化学研究室URL:
长崎国际大学药学部药物物理化学实验室 URL:
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
部分フッ素化アルコール(F6H9OH,F6H11OH)とDPPCの二成分単分子膜における相互作用
部分氟化醇 (F6H9OH、F6H11OH) 和 DPPC 的二元单层相互作用
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[吉岡弥生, 浅尾勝哉, 松谷晃宏,髙田綾子, 柴田攻]
通讯作者:
柴田攻
Langmuir monolayer properties of egg yolk lecithin with palmitic acid and hexadecanol
蛋黄卵磷脂与棕榈酸和十六醇的 Langmuir 单层特性
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[吉岡弥生, 浅尾勝哉, 柴田攻, Yayoi Yoshioka, 松谷晃宏,髙田綾子, 柴田 攻]
通讯作者:
柴田 攻
共 152 条
Development of Innovative Targeting Hybrid Artificial Pulmonary Surfactant Preparations by Nanomedicine
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批准号:26350534
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.08万
-
财政年份:2014
-
负责人:SHIBATA Osamu
-
依托单位:
Mechanisms of contraction/relaxation of airway smooth muscle : relationship between β-antagonist and Rho-kinase pathway
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批准号:19591804
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.66万
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财政年份:2007
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负责人:SHIBATA Osamu
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依托单位:
Basic research and development of de novo-designed peptide/fluorinated carbon hybrid artificial lung surfactant
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批准号:17310075
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$10.09万
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财政年份:2005
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负责人:SHIBATA Osamu
-
依托单位:
Mechanisms of airway smooth muscle contraction : physio-pharmacologic factors and intracellular signaling pathway
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批准号:15591638
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.79万
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财政年份:2003
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负责人:SHIBATA Osamu
-
依托单位:
Effects of Intravenous anesthetics on Phosphatidylinositol Response of Spinal Descending Inhibitory Pathways of Rat
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批准号:10671421
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.98万
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财政年份:1998
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负责人:SHIBATA Osamu
-
依托单位:
ROLES OF PHOSPHATIDYLINOSITOL IN THE MECHANISMS INVOLVED IN THE AIRWAY SMOOTH MUSCLE RELAXATION INDUCED BY ATP-SENSITIVE POTASSIUM CHANNEL OPENERS
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批准号:08671750
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.28万
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财政年份:1996
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负责人:SHIBATA Osamu
-
依托单位:
The Study on Two Dimensional Dynamic Process of Ionic Surfactants Composed of Fluorocarbon and Hydrocarbon Ions
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批准号:07672318
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.28万
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财政年份:1995
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负责人:SHIBATA Osamu
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依托单位:
Estimation of ultraviolet radiation as a limiting factor for vertical distribution of plants by studying their ultraviolet resistance.
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批准号:02804054
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.02万
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财政年份:1990
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负责人:SHIBATA Osamu
-
依托单位:
海外基金