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Mechanisms of contraction/relaxation of airway smooth muscle : relationship between β-antagonist and Rho-kinase pathway

Mechanisms of contraction/relaxation of airway smooth muscle : relationship between β-antagonist and Rho-kinase pathway
气道平滑肌收缩/舒张机制:β-拮抗剂与Rho激酶途径的关系
批准号:
19591804
负责人:
SHIBATA Osamu
金额:
$1.66万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2009

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中文摘要
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英文摘要
The results suggest that high concentrations of landiolol could cause airway smooth muscle contraction through the Rho-kinase pathway, but not through the PI response coupled with muscarinic M3 receptors, 5-HT receptors or the activation of L-type Ca(2+) channels.
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High concentrations of landiolol, a β1-adrenoceptor antagonist, stimulates smooth muscle contraction of the rat trachea through the Rho-kinase pathway
高浓度兰地洛尔(一种 β1 肾上腺素受体拮抗剂)通过 Rho 激酶途径刺激大鼠气管平滑肌收缩
DOI: --
发表时间: 2008
期刊: J Anesth 22
影响因子: --
作者: [Saito M, Shibata O, Tsuda A, Makita T, Sumikawa K, Osamu Shibata]
通讯作者: Osamu Shibata
Hyperosmolarity attenuates the contraction of rat trachea hrough the inhibition of phosphatidylinositol response
高渗透压通过抑制磷脂酰肌醇反应来减弱大鼠气管的收缩
DOI: --
发表时间: 2008
期刊: ActaMedicaNagasakiensia 52
影响因子: --
作者: [Saito M, Shibata O, Tsuda A, Makita T, Sumikawa K]
通讯作者: Sumikawa K
Development of Innovative Targeting Hybrid Artificial Pulmonary Surfactant Preparations by Nanomedicine
  • 批准号:
    26350534
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $3.08万
  • 财政年份:
    2014
  • 负责人:
    SHIBATA Osamu
  • 依托单位:
Development of Innovative Targeting Artificial pulmonary surfactant preparations by Nanomedicine
  • 批准号:
    23510134
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $3.49万
  • 财政年份:
    2011
  • 负责人:
    SHIBATA Osamu
  • 依托单位:
Basic research and development of de novo-designed peptide/fluorinated carbon hybrid artificial lung surfactant
Mechanisms of airway smooth muscle contraction : physio-pharmacologic factors and intracellular signaling pathway
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