The structure and function of new drug excreting transporter MATE in mannmal

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There are so many transporters in kidney and these transporters are concerned about transepithelial transport. These transporters don't work alone but may be working together. From this idea, drug excretion is precisely controlled and these should be well organized mechanism. MATE transporter is also controlled with these mechanism. In MATE transporter, there is long tail in C-terminus region, so, in this region should hove some function for regulation. From this hypothesis, several functional proteins are identified.