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Regulation of physiological functions with food factors via molecular chaperones

Regulation of physiological functions with food factors via molecular chaperones
通过分子伴侣利用食物因子调节生理功能
批准号:
23580164
负责人:
MURAKAMI Akira
金额:
$3.58万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2013

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英文摘要
Although phytochemicals have been reported to exhibit various physiological functions, their underlying mechanisms remain to be fully elucidated. We previously identified Keap1 as a target molecule of zerumbone, a major component of Zingiber zerumbet. Concomitantly, however, we also observed numerous binding proteins when cells were exposed to this phytochemical. Thus this study focused on the role(s) of non-specific protein binding in its bioactivities. Interestingly, zerumbone-induced proteo-stress up-regulated the expressions of molecular chaperones and increased autophagy for degradation of abnormal proteins. This is the first study that showed phytochemical-induced proteo-stress has significant and unique roles in their bioactivities.
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会议论文
ファイトケミカルによる生体タンパク質ストレスと健康効果
植物化学物质引起的生物蛋白质应激和健康影响
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [五十嵐庸, 鈴木香, 坂本廣司, 長岡功, 岩井邦久, 村上 明]
通讯作者: 村上 明
Molecular chaperones as the novel target of phytochemicals
分子伴侣作为植物化学物质的新靶点
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [五十嵐庸, 鈴木香, 坂本廣司, 長岡功, 侯 徳興, A. Murakami and K. Ohnishi.]
通讯作者: A. Murakami and K. Ohnishi.
ファイトケミカルによるproteo-stressとhormesis
植物化学物质的蛋白质应激和毒物兴奋作用
DOI: --
发表时间: 2014
期刊:
影响因子: --
作者: [Y. Uekaji, H. Yoshii et al., 村上明]
通讯作者: 村上明
②村上 明 、食べ物の健康効果を考える食 品機能学、兵庫県立兵庫高校にて授業 (2012年12月20日、神戸)(アウトリーチ活動)
② 村上晃,食品功能科学,考虑食品对健康的影响,兵库县立兵库高中授课(2012年12月20日,神户)(外展活动)
DOI: --
发表时间:
期刊:
影响因子: --
作者: []
通讯作者:
25
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    • 批准号:
      17K02535
    • 项目类别:
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    • 资助金额:
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    • 财政年份:
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