Regulation of physiological functions with food factors via molecular chaperones
Regulation of physiological functions with food factors via molecular chaperones
批准号:
23580164
负责人:
MURAKAMI Akira
金额:
$3.58万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2013
中文摘要
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英文摘要
Although phytochemicals have been reported to exhibit various physiological functions, their underlying mechanisms remain to be fully elucidated. We previously identified Keap1 as a target molecule of zerumbone, a major component of Zingiber zerumbet. Concomitantly, however, we also observed numerous binding proteins when cells were exposed to this phytochemical. Thus this study focused on the role(s) of non-specific protein binding in its bioactivities. Interestingly, zerumbone-induced proteo-stress up-regulated the expressions of molecular chaperones and increased autophagy for degradation of abnormal proteins. This is the first study that showed phytochemical-induced proteo-stress has significant and unique roles in their bioactivities.
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ファイトケミカルによる生体タンパク質ストレスと健康効果
植物化学物质引起的生物蛋白质应激和健康影响
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[五十嵐庸, 鈴木香, 坂本廣司, 長岡功, 岩井邦久, 村上 明]
通讯作者:
村上 明
Molecular chaperones as the novel target of phytochemicals
分子伴侣作为植物化学物质的新靶点
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[五十嵐庸, 鈴木香, 坂本廣司, 長岡功, 侯 徳興, A. Murakami and K. Ohnishi.]
通讯作者:
A. Murakami and K. Ohnishi.
ファイトケミカルによるproteo-stressとhormesis
植物化学物质的蛋白质应激和毒物兴奋作用
DOI:
--
发表时间:
2014
期刊:
影响因子:
--
作者:
[Y. Uekaji, H. Yoshii et al., 村上明]
通讯作者:
村上明
②村上 明 、食べ物の健康効果を考える食 品機能学、兵庫県立兵庫高校にて授業 (2012年12月20日、神戸)(アウトリーチ活動)
② 村上晃,食品功能科学,考虑食品对健康的影响,兵库县立兵库高中授课(2012年12月20日,神户)(外展活动)
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
ファイトケミカルは体に厳しいからこそ健康に良い
植物化学物质对健康有益,因为它们对身体有害
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[Chen J, Qin S, Xiao J, Tanigawa S, Uto T, Hashimoto F, Fujii M and Hou DX, 村上 明]
通讯作者:
村上 明
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US Culture ( and Soft Power ) of the Cold War era and Turn-of-the-Century Cultural and Political Issues
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Asset management of agricultural facilities considering risk evaluation of heavy rain/earthquake disaster
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Development of RNA-diagnosis system for the analysisi of RNA and RNA-protein complexes
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Atopic keratoconjunctivitis and natural helper cell
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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the Nationalism of the United States and Representations as Soft Power during the Cold War Era
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Asset management for the group of agricultural faclities based on the risk for soil erosion using the data assimilation
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Development of the general-purpose system for inverse analysis based on the statistical mathematics: application to performance-based design and maintenance of soil structures
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IFN-γPAI-1 signals in ocular complications of atopic diseases
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Development of novel functional oligonucleotide analogs for detection and regulation of a single base alteration in gene
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Roles of adipocytokines in colorectal carcinogenesis and identification of preventive food factors
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System of Functional Diagnosis for Stock Management of Soil Structures Based on Integrated Measurement/Data Assimilation
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Developments of in situ real-time monitoring system by fluorescent-probe and regulation protocols of functional RNAs
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Pharmacological control of genetic deficient in corneal dystrophies
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Effects of lauric acid on the production of pro-inflammatory mediators and its risk assessment
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Measurement system of shear banding formation of granular materials based on the particle image velocimetry(PIV) with the image processing device and the meshless analysis system for bifurcation behavior of the specimen
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项目类别:Grant-in-Aid for Scientific Research (B)
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财政年份:2002
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依托单位:
DESIGN OF FLUORESCENT RNA-PROBE FOR THE ANALYSIS OF THE HIGH-ORDER STRUCTURE OF RNA AND ITS APPLICATION TO THE GENE DESTRUCTION BY ANTISENSE OLIGONUCLEOTIDES
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Experimental and numerical approach for the behavior of granular medium within shear band
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Experimental and numerical approach for the behavior of granular medium within shear band
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R&D Studies of 3-dimentional particle tracking detector using CCD device for the particle physics
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依托单位:
海外基金