Regulation of mast cell responses by environmental factors
Regulation of mast cell responses by environmental factors
批准号:
23590077
负责人:
TANAKA Satoshi
金额:
$3.41万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2013
中文摘要
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英文摘要
This study was performed to clarify the mechanism under which microenvironmental factors, such as neighboring cells, extracellular matrices, and IgE, regulate the terminal differentiation of murine tissue mast cells. Sensitivity to non-IgE stimulus was augmented during the maturation of mast cells, whereas the potentials to produce inflammatory cytokines were decreased in matured mast cells. Higher concentrations of IgE induced a transient increase in cytokine production but suppressed antigen-induced degranulation and inflammatory cytokine production.
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マスト細胞の成熟過程におけるヒスタミンの機能
组胺在肥大细胞成熟过程中的作用
DOI:
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发表时间:
2011
期刊:
影响因子:
--
作者:
[温田晃子, 櫨木薫, 濁川清美, 益田彩加, 櫨木修, 中西郁夫, 田中智之]
通讯作者:
田中智之
岡山大学大学院医歯薬学総合研究科 生体応答制御学分野
冈山大学生物医学科学研究科生物反应控制系
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
ハロゲン化ジニトロベンゼンによる脱顆粒応答の解析
卤代二硝基苯引起的脱颗粒反应分析
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[真鍋 洋平, 柿木 彩, 穂刈 敏史, 吉村 麻里江, 宮地 弘幸, 田中 智之]
通讯作者:
田中 智之
創薬の標的としてのマスト細胞
肥大细胞作为药物发现的靶标
DOI:
--
发表时间:
2014
期刊:
MEDCHEM NEWS
影响因子:
--
作者:
[川島知憲, 中西郁夫, 大久保敬, 福住俊一, 安西和紀, 小澤俊彦, 松本謙一郎, 今中常雄, 田中 智之]
通讯作者:
田中 智之
Histamine synthesis and its functions in murine mast cells
小鼠肥大细胞中组胺的合成及其功能
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[上原政文, 櫨木薫, 濁川清美, 櫨木修, 久下 理, 中西郁夫, Satoshi Tanaka]
通讯作者:
Satoshi Tanaka
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