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The analyses of tight junction formation via disulfide bond

The analyses of tight junction formation via disulfide bond
二硫键紧密连接形成的分析
批准号:
22590336
负责人:
TANAKA Satoshi
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012

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中文摘要
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英文摘要
We found that occludin, a transmembrane protein found in tightjunctions, had an intra-molecular disulfide bond in its cytoplasmic tail of the c-terminus and that the ratio of disulfide bond formation depended on its sub-cellular location. In addition, we discovered that a disulfide bond in the extracellular loop of occludin might affect its stability. Co-immunoprecipitation with occludin containing a cysteine mutation revealed an associated with some kinds of protein thatmight regulate disulfide bond formation. We also found that zo-1, another tight junctionprotein, might have dimerized via a disulfide bond.
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細胞間結合装置、日本臨床分子形態学会編、病気の分子形態学、学際企画
细胞间连接装置,日本临床分子形态学会编,疾病分子形态学,跨学科项目
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [小島隆, 村田雅樹, 高澤啓, 田中敏, 澤田典均]
通讯作者: 澤田典均
Protein kinase Calpha inhibitor enhances the sensitivity of human pancreatic cancer HPAC cells to Clostridium perfringens enterotoxin via claudin-4
蛋白激酶Cα抑制剂通过claudin-4增强人胰腺癌HPAC细胞对产气荚膜梭菌肠毒素的敏感性
DOI: 10.1007/s00441-011-1287-2
发表时间: 2011
期刊: Cell Tiisue Res
影响因子: --
作者: [Kyuno D, Kojima T, Ito T, Yamaguchi H, Tsujiwaki M, Takasawa A, Murata M, Tanaka S, Hirata K, Sawada N]
通讯作者: Sawada N
DOI: 10.1136/jclinpath-2011-200400
发表时间: 2012-05-01
期刊: JOURNAL OF CLINICAL PATHOLOGY
影响因子: 3.4
作者: [Soini, Y., Takasawa, A., Sawada, N.]
通讯作者: Sawada, N.
胆道癌における claudin-18、maspin の免疫組織化学的検討
胆道癌claudin-18和maspin的免疫组织化学检查
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [高澤啓, 計良淑子, 村田雅樹, 荻野次郎, 及能大輔, 田中敏, 小島隆, 長谷川匡, 澤田典均]
通讯作者: 澤田典均
25
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    The function of disulfide bond in tight junction protein, as an oxidative sensor
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