The analyses of tight junction formation via disulfide bond
The analyses of tight junction formation via disulfide bond
批准号:
22590336
负责人:
TANAKA Satoshi
金额:
$2.91万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
点击翻译按钮获取中文摘要
英文摘要
We found that occludin, a transmembrane protein found in tightjunctions, had an intra-molecular disulfide bond in its cytoplasmic tail of the c-terminus and that the ratio of disulfide bond formation depended on its sub-cellular location. In addition, we discovered that a disulfide bond in the extracellular loop of occludin might affect its stability. Co-immunoprecipitation with occludin containing a cysteine mutation revealed an associated with some kinds of protein thatmight regulate disulfide bond formation. We also found that zo-1, another tight junctionprotein, might have dimerized via a disulfide bond.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
登录
查看更多内容
細胞間結合装置、日本臨床分子形態学会編、病気の分子形態学、学際企画
细胞间连接装置,日本临床分子形态学会编,疾病分子形态学,跨学科项目
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[小島隆, 村田雅樹, 高澤啓, 田中敏, 澤田典均]
通讯作者:
澤田典均
Protein kinase Calpha inhibitor enhances the sensitivity of human pancreatic cancer HPAC cells to Clostridium perfringens enterotoxin via claudin-4
蛋白激酶Cα抑制剂通过claudin-4增强人胰腺癌HPAC细胞对产气荚膜梭菌肠毒素的敏感性
DOI:
10.1007/s00441-011-1287-2
发表时间:
2011
期刊:
Cell Tiisue Res
影响因子:
--
作者:
[Kyuno D, Kojima T, Ito T, Yamaguchi H, Tsujiwaki M, Takasawa A, Murata M, Tanaka S, Hirata K, Sawada N]
通讯作者:
Sawada N
DOI:
10.1136/jclinpath-2011-200400
发表时间:
2012-05-01
期刊:
JOURNAL OF CLINICAL PATHOLOGY
影响因子:
3.4
作者:
[Soini, Y., Takasawa, A., Sawada, N.]
通讯作者:
Sawada, N.
胆道癌における claudin-18、maspin の免疫組織化学的検討
胆道癌claudin-18和maspin的免疫组织化学检查
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[高澤啓, 計良淑子, 村田雅樹, 荻野次郎, 及能大輔, 田中敏, 小島隆, 長谷川匡, 澤田典均]
通讯作者:
澤田典均
卵巣癌細胞株におけるタイト結合分子claudin-4 に対する CPE 作用条件についての検討
CPE对卵巢癌细胞系紧密连接分子claudin-4作用条件的研究
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[井上万梨絵, 田中敏, 染谷真行, 高澤啓, 村田雅樹, 小島隆, 斎藤豪, 澤田典均]
通讯作者:
澤田典均
共 25 条
Development of penetrator probe for volcano monitoring deployed from unmanned aerial vehicle
-
批准号:15H01793
-
项目类别:Grant-in-Aid for Scientific Research (A)
-
资助金额:$24.63万
-
财政年份:2015
-
负责人:TANAKA Satoshi
-
依托单位:
Mechanisms of persistent postoperative pain after laparotomy and analgesic treatments
-
批准号:26462380
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.08万
-
财政年份:2014
-
负责人:TANAKA Satoshi
-
依托单位:
Analysis of visual perception cognitive pattern aiming at efficiency of dental medical education
-
批准号:26463196
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.08万
-
财政年份:2014
-
负责人:TANAKA Satoshi
-
依托单位:
The function of disulfide bond in tight junction protein, as an oxidative sensor
-
批准号:26460455
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.24万
-
财政年份:2014
-
负责人:TANAKA Satoshi
-
依托单位:
Developing Educational Model for Disaster Prevention by Supporting Cross-subject Cooperation
-
批准号:25285244
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$10.4万
-
财政年份:2013
-
负责人:TANAKA Satoshi
-
依托单位:
Analysis of Life Recovery Process of the Government-rented Temporary Housing Dwellers
-
批准号:25560183
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.41万
-
财政年份:2013
-
负责人:TANAKA Satoshi
-
依托单位:
Studies of activities of daily living and dementia of inpatients, burden of medical staffs duties, and medical security by life supports for inpatients that nurses and rehabilitation staffs result in.
-
批准号:24593246
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.49万
-
财政年份:2012
-
负责人:TANAKA Satoshi
-
依托单位:
Studies on the role of LIN28A in mouse trophoblast stem cell
-
批准号:24248048
-
项目类别:Grant-in-Aid for Scientific Research (A)
-
资助金额:$28.37万
-
财政年份:2012
-
负责人:TANAKA Satoshi
-
依托单位:
Theory of one-dimensional electronic Casimir effect in terms of complex eigenvalue problem of Hamiltonian and Liouvilian
-
批准号:24540327
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.33万
-
财政年份:2012
-
负责人:TANAKA Satoshi
-
依托单位:
The number of nonoscillatory solutions and the length and the fractal dimension for two-point boundary value problems
-
批准号:23740113
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$1.66万
-
财政年份:2011
-
负责人:TANAKA Satoshi
-
依托单位:
Regulation of mast cell responses by environmental factors
-
批准号:23590077
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.41万
-
财政年份:2011
-
负责人:TANAKA Satoshi
-
依托单位:
Facilitation of motor learning by non-invasive brain stimulation
-
批准号:22700442
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.58万
-
财政年份:2010
-
负责人:TANAKA Satoshi
-
依托单位:
Visual Analysis of medical volume data using numerical differential calculus based on accuracy-tunable smoothing
-
批准号:22500100
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.0万
-
财政年份:2010
-
负责人:TANAKA Satoshi
-
依托单位:
Developing guidelines for designing educational materials to enhance learners' motivation by using subjective evaluation criteria
-
批准号:22500881
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.83万
-
财政年份:2010
-
负责人:TANAKA Satoshi
-
依托单位:
Studies on the dementia and activities of daily living of inpatients on early stages of illness, and on the burden of nurses.
-
批准号:21592719
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.0万
-
财政年份:2009
-
负责人:TANAKA Satoshi
-
依托单位:
Nonequilibrium transport of vibrational excitation in alpha-helix molecular chain and ultrafast X-ray spectroscopy
-
批准号:21540324
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.91万
-
财政年份:2009
-
负责人:TANAKA Satoshi
-
依托单位:
Immune modulatory functions of mature mast cells
-
批准号:21790100
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.66万
-
财政年份:2009
-
负责人:TANAKA Satoshi
-
依托单位:
Epigenetics on transdifferentiation of ES cells toward TS cells
-
批准号:21248039
-
项目类别:Grant-in-Aid for Scientific Research (A)
-
资助金额:$18.64万
-
财政年份:2009
-
负责人:TANAKA Satoshi
-
依托单位:
Fabrication Processing based on Kinetics for Crystal-Oriented Ceramics using a Magnetic Field and Subsequent Sintering
-
批准号:20686045
-
项目类别:Grant-in-Aid for Young Scientists (A)
-
资助金额:$16.47万
-
财政年份:2008
-
负责人:TANAKA Satoshi
-
依托单位:
Synergistic Effects of Therapeutic Exercise in a Virtual Environment on Physical and Cognitive Functions of the Elderly
-
批准号:20500485
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.0万
-
财政年份:2008
-
负责人:TANAKA Satoshi
-
依托单位:
海外基金