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Epigenetics on transdifferentiation of ES cells toward TS cells

Epigenetics on transdifferentiation of ES cells toward TS cells
ES细胞向TS细胞转分化的表观遗传学
批准号:
21248039
负责人:
TANAKA Satoshi
金额:
$18.64万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (A)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011

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中文摘要
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英文摘要
To elucidate if mESCs pass through TSC-like and/or EpiSC-like state during the process of BMP4-induced transdifferentiation, we investigated nature of intermediate cell population in the transdifferentiation process. Immunohistochemistry revealed the presence of TSC-like cell colonies only in the BMP4-treated cultures. We then subcultured BMP4-treated mESCs under the conditions for maintenance of TSCs, and consequently obtained a cell line. DNA microarray analysis revealed that the gene expression profile of then new cell line is more similar to that of EpiSCs compared to mTSCs and mESCs. These results suggest that BMP4-treated mESCs may transdifferentiate to TCs through two independent pathways. One is the pathway through mTSC-like state and the other through mEpiSC-like state.
期刊论文(4)
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会议论文
Study on a BMP4-induced transdifferentiation process of mouse embryonic stem cells toward trophoblast cell fate
BMP4诱导小鼠胚胎干细胞向滋养层细胞转分化过程的研究
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Fuyuki Adachi, et al.]
通讯作者: et al.
TS細胞をもちいたトロホブラスト研究-クローン胚のトロホブラストは異常か?
使用 TS 细胞进行滋养层研究 - 克隆胚胎的滋养层是否异常?
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [Nobuhisa I, Osawa M, Uemura M, Kishikawa Y, Anani M, Harada K, Takagi H, Kudo A, Kanai-Azuma M, Kanai Y, Iwama A, Taga T., 田中智]
通讯作者: 田中智
TS細胞をもちいたトロホブラスト研究-クローン胚のトロホブラストは異常か?-
使用TS细胞进行滋养层研究 -克隆胚胎的滋养层是否异常?-
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [M.Nakamura, Y.suzuki, Y.Otsuka, T.Kawakami, K. Sato, S.Kajita, S.Hishiyama. A.Takahashi, Y.Katayama, 三輪加奈, 田中智]
通讯作者: 田中智
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Fuyuki Adachi, Kunio Shiota and Satoshi Tanaka]
通讯作者: Kunio Shiota and Satoshi Tanaka
Development of penetrator probe for volcano monitoring deployed from unmanned aerial vehicle
  • 批准号:
    15H01793
  • 项目类别:
    Grant-in-Aid for Scientific Research (A)
  • 资助金额:
    $24.63万
  • 财政年份:
    2015
  • 负责人:
    TANAKA Satoshi
  • 依托单位:
Mechanisms of persistent postoperative pain after laparotomy and analgesic treatments
  • 批准号:
    26462380
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $3.08万
  • 财政年份:
    2014
  • 负责人:
    TANAKA Satoshi
  • 依托单位:
Analysis of visual perception cognitive pattern aiming at efficiency of dental medical education
  • 批准号:
    26463196
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $3.08万
  • 财政年份:
    2014
  • 负责人:
    TANAKA Satoshi
  • 依托单位:
The function of disulfide bond in tight junction protein, as an oxidative sensor
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