Epigenetics on transdifferentiation of ES cells toward TS cells
Epigenetics on transdifferentiation of ES cells toward TS cells
批准号:
21248039
负责人:
TANAKA Satoshi
金额:
$18.64万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (A)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
点击翻译按钮获取中文摘要
英文摘要
To elucidate if mESCs pass through TSC-like and/or EpiSC-like state during the process of BMP4-induced transdifferentiation, we investigated nature of intermediate cell population in the transdifferentiation process. Immunohistochemistry revealed the presence of TSC-like cell colonies only in the BMP4-treated cultures. We then subcultured BMP4-treated mESCs under the conditions for maintenance of TSCs, and consequently obtained a cell line. DNA microarray analysis revealed that the gene expression profile of then new cell line is more similar to that of EpiSCs compared to mTSCs and mESCs. These results suggest that BMP4-treated mESCs may transdifferentiate to TCs through two independent pathways. One is the pathway through mTSC-like state and the other through mEpiSC-like state.
期刊论文(4)
专著(0)
科研奖励(0)
会议论文
登录
查看更多内容
Study on a BMP4-induced transdifferentiation process of mouse embryonic stem cells toward trophoblast cell fate
BMP4诱导小鼠胚胎干细胞向滋养层细胞转分化过程的研究
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Fuyuki Adachi, et al.]
通讯作者:
et al.
TS細胞をもちいたトロホブラスト研究-クローン胚のトロホブラストは異常か?
使用 TS 细胞进行滋养层研究 - 克隆胚胎的滋养层是否异常?
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Nobuhisa I, Osawa M, Uemura M, Kishikawa Y, Anani M, Harada K, Takagi H, Kudo A, Kanai-Azuma M, Kanai Y, Iwama A, Taga T., 田中智]
通讯作者:
田中智
Study on a BMP4-induced transdifferentiation process of mouse embryonic stem cells toward trophoblast cell fate. The 2^nd World Congress on Reproductive Biology
BMP4诱导小鼠胚胎干细胞向滋养层细胞命运转分化过程的研究。
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Fuyuki Adachi, Kunio Shiota and Satoshi Tanaka]
通讯作者:
Kunio Shiota and Satoshi Tanaka
TS細胞をもちいたトロホブラスト研究-クローン胚のトロホブラストは異常か?-
使用TS细胞进行滋养层研究 -克隆胚胎的滋养层是否异常?-
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[M.Nakamura, Y.suzuki, Y.Otsuka, T.Kawakami, K. Sato, S.Kajita, S.Hishiyama. A.Takahashi, Y.Katayama, 三輪加奈, 田中智]
通讯作者:
田中智
Development of penetrator probe for volcano monitoring deployed from unmanned aerial vehicle
-
批准号:15H01793
-
项目类别:Grant-in-Aid for Scientific Research (A)
-
资助金额:$24.63万
-
财政年份:2015
-
负责人:TANAKA Satoshi
-
依托单位:
Mechanisms of persistent postoperative pain after laparotomy and analgesic treatments
-
批准号:26462380
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.08万
-
财政年份:2014
-
负责人:TANAKA Satoshi
-
依托单位:
Analysis of visual perception cognitive pattern aiming at efficiency of dental medical education
-
批准号:26463196
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.08万
-
财政年份:2014
-
负责人:TANAKA Satoshi
-
依托单位:
The function of disulfide bond in tight junction protein, as an oxidative sensor
-
批准号:26460455
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.24万
-
财政年份:2014
-
负责人:TANAKA Satoshi
-
依托单位:
Developing Educational Model for Disaster Prevention by Supporting Cross-subject Cooperation
-
批准号:25285244
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$10.4万
-
财政年份:2013
-
负责人:TANAKA Satoshi
-
依托单位:
Analysis of Life Recovery Process of the Government-rented Temporary Housing Dwellers
-
批准号:25560183
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.41万
-
财政年份:2013
-
负责人:TANAKA Satoshi
-
依托单位:
Studies of activities of daily living and dementia of inpatients, burden of medical staffs duties, and medical security by life supports for inpatients that nurses and rehabilitation staffs result in.
-
批准号:24593246
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.49万
-
财政年份:2012
-
负责人:TANAKA Satoshi
-
依托单位:
Studies on the role of LIN28A in mouse trophoblast stem cell
-
批准号:24248048
-
项目类别:Grant-in-Aid for Scientific Research (A)
-
资助金额:$28.37万
-
财政年份:2012
-
负责人:TANAKA Satoshi
-
依托单位:
Theory of one-dimensional electronic Casimir effect in terms of complex eigenvalue problem of Hamiltonian and Liouvilian
-
批准号:24540327
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.33万
-
财政年份:2012
-
负责人:TANAKA Satoshi
-
依托单位:
The number of nonoscillatory solutions and the length and the fractal dimension for two-point boundary value problems
-
批准号:23740113
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$1.66万
-
财政年份:2011
-
负责人:TANAKA Satoshi
-
依托单位:
Regulation of mast cell responses by environmental factors
-
批准号:23590077
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.41万
-
财政年份:2011
-
负责人:TANAKA Satoshi
-
依托单位:
Facilitation of motor learning by non-invasive brain stimulation
-
批准号:22700442
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.58万
-
财政年份:2010
-
负责人:TANAKA Satoshi
-
依托单位:
The analyses of tight junction formation via disulfide bond
-
批准号:22590336
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.91万
-
财政年份:2010
-
负责人:TANAKA Satoshi
-
依托单位:
Visual Analysis of medical volume data using numerical differential calculus based on accuracy-tunable smoothing
-
批准号:22500100
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.0万
-
财政年份:2010
-
负责人:TANAKA Satoshi
-
依托单位:
Developing guidelines for designing educational materials to enhance learners' motivation by using subjective evaluation criteria
-
批准号:22500881
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.83万
-
财政年份:2010
-
负责人:TANAKA Satoshi
-
依托单位:
Studies on the dementia and activities of daily living of inpatients on early stages of illness, and on the burden of nurses.
-
批准号:21592719
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.0万
-
财政年份:2009
-
负责人:TANAKA Satoshi
-
依托单位:
Nonequilibrium transport of vibrational excitation in alpha-helix molecular chain and ultrafast X-ray spectroscopy
-
批准号:21540324
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.91万
-
财政年份:2009
-
负责人:TANAKA Satoshi
-
依托单位:
Immune modulatory functions of mature mast cells
-
批准号:21790100
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.66万
-
财政年份:2009
-
负责人:TANAKA Satoshi
-
依托单位:
Fabrication Processing based on Kinetics for Crystal-Oriented Ceramics using a Magnetic Field and Subsequent Sintering
-
批准号:20686045
-
项目类别:Grant-in-Aid for Young Scientists (A)
-
资助金额:$16.47万
-
财政年份:2008
-
负责人:TANAKA Satoshi
-
依托单位:
A study on the number of sign-changing solutions of two-point boundary value problems and its application
-
批准号:20740082
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$1.33万
-
财政年份:2008
-
负责人:TANAKA Satoshi
-
依托单位:
海外基金