Roles of the androgen receptor in the sexual differentiation in the mouse submandibular gland
Roles of the androgen receptor in the sexual differentiation in the mouse submandibular gland
批准号:
23590231
负责人:
ISEKI Shoichi
金额:
$3.41万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2013
中文摘要
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英文摘要
We examined the SMG of mice deficient of the androgen receptor (ARKO). The development of granular convoluted tubules (GCT) in ARKO male was as low as in control female. The administration of androgens had no effect, whereas the administration of thyroid hormone (T4) caused the conversion of striated duct cells into GCT cells in ARKO SMG. These results confirmed that GCT differentiation caused by androgens is dependent on the classical androgen receptor (AR), whereas that by T4 is independent of the AR. Analysis of the gene expression profiles in ARKO SMG revealed new GCT-specific genes as well as genes up-or down-regulated in the SMG by androgens without involvement of the classical AR.
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DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Adthapanyawanich K, Nakata H, Yamamoto, M, Yamagishi R, Wakayama T, Iseki S]
通讯作者:
Iseki S
マウス顎下腺および舌下腺におけるαアミラーゼの発現と局在
α-淀粉酶在小鼠颌下腺和舌下腺中的表达和定位
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[山岸諒子, Kannika Adthapanyawanich, 仲田浩規, 山本美由紀, 若山友彦, 井関尚一]
通讯作者:
井関尚一
The duct system of mouse submandibular gland as a model of hormone-dependent cell differentiation
小鼠颌下腺导管系统作为激素依赖性细胞分化的模型
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Sato, S., Ikeda, K., Shioi, G., Nakao, K., Yajima, H., Kawakami, K, 藤田 秋一, Iseki S]
通讯作者:
Iseki S
Expression and localization of receptor protein tyrosine phosphatase b and its ligand pleiotrophin in the submandibular gland of mice
受体蛋白酪氨酸磷酸酶b及其配体多效蛋白在小鼠颌下腺中的表达及定位
DOI:
10.1016/j.archoralbio.2012.09.005
发表时间:
2013
期刊:
Archives of Oral Biology
影响因子:
--
作者:
[Adthapanyawanich K, Yamamoto M, Wakayama T, Nakata H, Keattikunpairoj S, Iseki S]
通讯作者:
Iseki S
DOI:
10.1267/ahc.14005
发表时间:
2014-06-28
期刊:
Acta histochemica et cytochemica
影响因子:
2.4
作者:
[Yamagishi R, Wakayama T, Nakata H, Adthapanyawanich K, Kumchantuek T, Yamamoto M, Iseki S]
通讯作者:
Iseki S
共 17 条
Molecular mechanisms in the hormone-dependent differentiation of the mouse submandibular gland
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批准号:26460270
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.24万
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财政年份:2014
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负责人:ISEKI Shoichi
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依托单位:
Study on the functional mechanisms of androgens in differentiation of the mouse submandibular gland
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批准号:20590187
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.0万
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财政年份:2008
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负责人:ISEKI Shoichi
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依托单位:
GENE EXPRESSION DURING THE DUCT CELL DIFFERENTIATION IN SALIVARY GLANDS
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批准号:17590154
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
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财政年份:2005
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负责人:ISEKI Shoichi
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依托单位:
The mechanism of androgen-dependent differentiation of the duct system in the submandibular gland
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批准号:15590156
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
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财政年份:2003
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负责人:ISEKI Shoichi
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依托单位:
The signal-transduction mechanisms of the cell proliferation and differentiation in the submandibular gland
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批准号:13670006
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.62万
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财政年份:2001
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负责人:ISEKI Shoichi
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依托单位:
Expression and localization of vascular endothelial growth factor in the endocrine system
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批准号:09670006
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.05万
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财政年份:1997
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负责人:ISEKI Shoichi
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依托单位:
A histochemical study on the expression and localization of growth factors
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批准号:06670014
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.34万
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财政年份:1994
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负责人:ISEKI Shoichi
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依托单位:
Expression and localization of intestine-derived faty acid-binding proteins in the rat
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批准号:04670009
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.28万
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财政年份:1992
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负责人:ISEKI Shoichi
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依托单位:
Immunohistochemical Study on the Occurrence, Morphology and Development of the Gastrointestinal Brush Cells of the Rat
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批准号:01570006
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.34万
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财政年份:1989
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负责人:ISEKI Shoichi
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依托单位:
海外基金