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Development of human monoclonal antibodies to major surface antigens of parasitic protozoa for clinical applications

Development of human monoclonal antibodies to major surface antigens of parasitic protozoa for clinical applications
开发针对寄生原虫主要表面抗原的人单克隆抗体用于临床应用
批准号:
23590496
负责人:
TACHIBANA Hiroshi
金额:
$3.33万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2013

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中文摘要
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英文摘要
Whole human monoclonal IgG molecules were prepared from a Fab fragment specific to the C-terminus 19-kDa fragment of Plasmodium falciparum merozoite surface protein 1. Affinities of IgG1 and IgG3 molecules produced in CHO cells were approximately 20-fold higher than that of the original Fab fragment. Whole human IgG1 molecule was also prepared from a monoclonal antibody Fab fragment specific for surface lectin of Entamoeba histolytica. These whole human IgG molecules may be applicable for prevention, diagnosis and therapy of protozoan infectious diseases.
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Polymorphism in and antibody responses to thrombospondin-related adhesive protein of Plasmodium vivax (PvTRAP)
间日疟原虫血小板反应蛋白相关粘附蛋白 (PvTRAP) 的多态性和抗体反应
DOI: --
发表时间: 2014
期刊:
影响因子: --
作者: [Rattiporn Kosuwin, Meng Feng, Chaturong Putaporntip, Takashi Makiuchi, Hiroshi Tachibana, Somchai Jongwutiwes]
通讯作者: Somchai Jongwutiwes
ネパールのカトマンズにおける腸管寄生アメーバ感染の疫学研究
尼泊尔加德满都肠道寄生阿米巴原虫感染流行病学研究
DOI: --
发表时间:
期刊:
影响因子: --
作者: [館岡千佳, 六本木沙織, 森澤さおり, 飯塚一平, 鈴木義之, 小笠原渉, 田中信忠, 阪本泰光, 野中孝昌, 橘 裕司 他]
通讯作者: 橘 裕司 他
Chapter 8. Production of antibody Fab fragments in Escherichia coli. In: Al-Rubeai M(Ed.) Antibody Expression and Production. Cell Engineering 7
第 8 章:大肠杆菌中抗体 Fab 片段的生产。见:Al-Rubeai M(编辑)抗体细胞工程 7。
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Tachibana H., Takekoshi M.]
通讯作者: Takekoshi M.
Correlation between tRNA-linked short tandem repeats genes in Entamoeba nuttalli isolates and the geographical distribution of host macaques
内阿米巴分离株中 tRNA 连接的短串联重复基因与宿主猕猴地理分布的相关性
DOI: --
发表时间: 2014
期刊:
影响因子: --
作者: [Meng Feng, Tomoyoshi Komiyama, Tetsuo Yanagi, Xunjia Cheng, Jeevan B. Sherchand, Hiroshi Tachibana]
通讯作者: Hiroshi Tachibana
20
    Establishment and evaluation of a rapid diagnosis using nanotechnology for amebiasis
    • 批准号:
      17K08811
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.08万
    • 财政年份:
      2017
    • 负责人:
      TACHIBANA Hiroshi
    • 依托单位:
    Isolation of pathogenic Entamoeba species from humans and macaques in Asia and analysis of host-parasite coevolution
    • 批准号:
      16H05819
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $11.07万
    • 财政年份:
      2016
    • 负责人:
      TACHIBANA Hiroshi
    • 依托单位:
    Development of a rapid diagnostic test for amebiasis by using fluorescent nanoparticles
    • 批准号:
      26460516
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.24万
    • 财政年份:
      2014
    • 负责人:
      TACHIBANA Hiroshi
    • 依托单位:
    Studies on geographical distribution and genomic diversity of a new pathogenic Entamoeba species in Asia
    • 批准号:
      24406013
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $11.07万
    • 财政年份:
      2012
    • 负责人:
      TACHIBANA Hiroshi
    • 依托单位:
    海外基金