Examination for genomic biomarkers of intestinal and renal drug transporters aiming for the personalized medicine

该研究检查了药物转运蛋白的单核苷酸多态性（SNP）的类型和频率，这可能有助于健康日本志愿者中加巴喷丁药代动力学的个体间变异性。关于L-型氨基酸转运蛋白2（LAT 2）的未知SNP，加巴喷丁的吸收在两名普通等位基因纯合子受试者、四名杂合子受试者和一名突变等位基因纯合子受试者中依次增加。在73名日本人中，这些基因型的频率分别为22%、45%和22%。有机阳离子转运蛋白1（OCTN 1）和多药和毒素排出蛋白1（MATE 1）的未知SNP在加巴喷丁肾排泄低的受试者中发现，在该人群中未检测到。

The study examined a type and frequency of single nucleotide polymorphisms (SNPs) of the drug transporters which may contribute to the inter-individual variability of pharmacokinetics of gabapentin in healthy Japanese volunteers. Regarding with the unknown SNP of L-type amino acid transporter 2 (LAT2), absorption of gabapentin increased in two subjects homozygous for the common allele, four subjects heterozygous and one subject homozygous for the mutant allele in this order. Frequency of these genotypes were 22, 45 and 22%, respectively in 73 Japanese. The unknown SNPs of organic cation transporter 1 (OCTN1) and multidrug and toxin extrusion protein 1 (MATE1) found in one subject whose renal excretion of gabapentin was low, were not detected in this population.