Examination for genomic biomarkers of intestinal and renal drug transporters aiming for the personalized medicine

该研究检测了药物转运体的单核苷酸多态性（snp）的类型和频率，这可能有助于加巴喷丁在健康日本志愿者体内的药代动力学的个体间差异。对于l型氨基酸转运体2 （LAT2）的SNP未知，加巴喷丁吸收增加的顺序为：普通等位基因纯合子2例，杂合子4例，突变等位基因纯合子1例。这些基因型在73例日本人中分别占22%、45%和22%。在加巴喷丁肾排泄低的1例受试者中发现了未知的有机阳离子转运蛋白1 （OCTN1）和多药和毒素挤出蛋白1 (MATE1) snp，但未在该人群中检测到。

The study examined a type and frequency of single nucleotide polymorphisms (SNPs) of the drug transporters which may contribute to the inter-individual variability of pharmacokinetics of gabapentin in healthy Japanese volunteers. Regarding with the unknown SNP of L-type amino acid transporter 2 (LAT2), absorption of gabapentin increased in two subjects homozygous for the common allele, four subjects heterozygous and one subject homozygous for the mutant allele in this order. Frequency of these genotypes were 22, 45 and 22%, respectively in 73 Japanese. The unknown SNPs of organic cation transporter 1 (OCTN1) and multidrug and toxin extrusion protein 1 (MATE1) found in one subject whose renal excretion of gabapentin was low, were not detected in this population.