Investigation of the pathogenetic factors for the development of NASH

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Hyper-secretion of inflammatory cytokines from Kupffer cells and impairment of phagocytic function of Kupffer cells are considered to be important pathogenic factors for development of nonalcholic steatohepatitis (NASH). We clarified that number of CD11b+ Kupffer cells which enable to secrete inflammatory cytokines increase, and CD68+ Kupffer cells which enable to phagocyte and production of ROS decrease in NASH livers. In distribution, Kupffer cells distributed on whole hepatic lobes in the livers of NASH unlike normal livers. It was clarified and reported that the changes of subset and the distributions of Kupffer cells would be important pathogenic factors for development of NASH at several domestic and international medical meeting and some articles.